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The World Health Organization has recommended fortification of foods with vitamin D, but this is often challenging because of its low water solubility, poor chemical stability, and low bioavailability. Studies have shown that these challenges can be overcome by encapsulating vitamin D within well\u2010designed delivery systems containing nanoscale or microscale particles. The characteristics of these particles, such as their composition, size, structure, interfacial properties, and charge, can be controlled to attain desired functionality for specific applications. Recently, there has been great interest in the design, production, and application of vitamin\u2010D loaded delivery systems. Many of the delivery systems reported in the literature are unsuitable for widespread application due to the complexity and high costs of the processing operations required to fabricate them, or because they are incompatible with food matrices. In this article, the concept of \u201cfortification by design\u201d is introduced, which involves a systematic approach to the design, production, and testing of colloidal delivery systems for the encapsulation and fortification of oil\u2010soluble vitamins, using vitamin D as a model. Initially, the challenges associated with the incorporation of vitamin D into foods and beverages are reviewed. The fortification by design concept is then described, which involves several steps: (i) selection of appropriate vitamin D form; (ii) selection of appropriate food matrix; (iii) identification of appropriate delivery system; (iv) identification of appropriate production method; (vii) establishment of appropriate testing procedures; and (viii) system optimization.<\/jats:p>","DOI":"10.1111\/1541-4337.13066","type":"journal-article","created":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T03:48:37Z","timestamp":1670212117000},"page":"135-186","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Fortification by design: A rational approach to designing vitamin D delivery systems for foods and beverages"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5915-2197","authenticated-orcid":false,"given":"Vaibhav Kumar","family":"Maurya","sequence":"first","affiliation":[{"name":"Centre for Food Research and Analysis National Institute of Food Technology Entrepreneurship and Management  Sonepat India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5358-2567","authenticated-orcid":false,"given":"Amita","family":"Shakya","sequence":"additional","affiliation":[{"name":"Agriculture and Environmental Sciences National Institute of Food Technology Entrepreneurship and Management  Sonepat India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8191-4263","authenticated-orcid":false,"given":"Khalid","family":"Bashir","sequence":"additional","affiliation":[{"name":"Department of Food Technology Jamia Hamdard  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kulsum","family":"Jan","sequence":"additional","affiliation":[{"name":"Department of Food Technology Jamia Hamdard  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9016-1291","authenticated-orcid":false,"given":"David Julian","family":"McClements","sequence":"additional","affiliation":[{"name":"Department of Food Science University of Massachusetts  Amherst Massachusetts USA"},{"name":"Department of Food Science &amp; Bioengineering Zhejiang Gongshang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,13]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2013.08.018"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ps\/77.5.666"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ps\/77.4.570"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/10942912.2021.1953069"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4731(90)90160-T"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2013.07.006"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/1541-4337.12725"},{"issue":"3","key":"e_1_2_12_9_1","first-page":"526","article-title":"Microspheres as a novel drug delivery system\u2010a review","volume":"1","author":"Alagusundaram M.","year":"2009","journal-title":"International Journal of Drug Research and Technology"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2017.1323723"},{"issue":"1","key":"e_1_2_12_11_1","first-page":"1279","article-title":"Fortify soft cheese with liposomal vitamin D3","volume":"21","author":"Al\u2010mosowy A. 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