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This review investigates the global hazards of DON, describes the occurrence of DON in food and feed in different countries, and systematically uncovers the mechanisms of the various toxic effects of DON. For DON pollution, many treatments have been reported on the degradation of DON, and each of the treatments has different degradation efficacies and degrades DON by a distinct mechanism. These treatments include physical, chemical, and biological methods and mitigation strategies. Biodegradation methods include microorganisms, enzymes, and biological antifungal agents, which are of great research significance in food processing because of their high efficiency, low environmental hazards, and drug resistance. And we also reviewed the mechanisms of biodegradation methods of DON, the adsorption and antagonism effects of microorganisms, and the different chemical transformation mechanisms of enzymes. Moreover, nutritional mitigation including common nutrients (amino acids, fatty acids, vitamins, and microelements) and plant extracts was discussed in this review, and the mitigation mechanism of DON toxicity was elaborated from the biochemical point of view. These findings help explore various approaches to achieve the best efficiency and applicability, overcome DON pollution worldwide, ensure the sustainability and safety of food processing, and explore potential therapeutic options with the ability to reduce the deleterious effects of DON in humans and animals.<\/jats:p>","DOI":"10.1111\/1541-4337.13203","type":"journal-article","created":{"date-parts":[[2023,7,8]],"date-time":"2023-07-08T08:39:45Z","timestamp":1688805585000},"page":"3951-3983","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":94,"title":["Global distribution, toxicity to humans and animals, biodegradation, and nutritional mitigation of deoxynivalenol: A review"],"prefix":"10.1111","volume":"22","author":[{"given":"Yuang","family":"Tu","sequence":"first","affiliation":[{"name":"College of Animal Sciences Zhejiang University  Hangzhou China"},{"name":"Key Laboratory of Molecular Animal Nutrition (Zhejiang 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