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However, it is important to note that certain proteins present in mango can trigger various allergic reactions, ranging from mild oral allergy syndrome to severe life\u2010threatening anaphylaxis. The immunoglobulin E\u2010mediated hypersensitivity of mango is mainly associated with three major allergenic proteins: Man i 1 (class IV chitinase), Man i 2 (pathogenesis\u2010related\u201010 protein; Bet v 1\u2010related protein), and Man i 4 (profilin). Food processing techniques can significantly affect the structure of mango allergens, reducing their potential to cause allergies. However, it is worth mentioning that complete elimination of mango allergen immunoreactivity has not been achieved. The protection of individuals sensitized to mango should be carefully managed through an avoidance diet, immediate medical care, and long\u2010term oral immunotherapy. This review covers various aspects related to mango allergy, including prevalence, pathogenesis, symptoms, and diagnosis. Furthermore, the characterization of mango allergens and their potential cross\u2010reactivity with other fruits, vegetables, plant pollen, and seeds were discussed. The review also highlights the effects of food processing on mango and emphasizes the available strategies for managing mango allergy.\n                  <\/jats:p>","DOI":"10.1111\/1541-4337.13304","type":"journal-article","created":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T02:44:13Z","timestamp":1707705853000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["A comprehensive review on mango allergy: Clinical relevance, causative allergens, cross\u2010reactivity, influence of processing techniques, and management strategies"],"prefix":"10.1111","volume":"23","author":[{"given":"Jinlong","family":"Zhao","sequence":"first","affiliation":[{"name":"Key Laboratory of Environmental Medicine and Engineering, Ministry of Education, and Department of Nutrition and Food Hygiene School of Public Health Southeast University  Nanjing China"},{"name":"School of Food Engineering Anhui Science and Technology University  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