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Differences in cheesemaking change the cheese microenvironment, thereby affecting cheese flavor profiles. A framework for tuning cheese flavor is proposed in this study, which depicts the full picture of flavor development and modulation, from manufacturing and ripening factors through the main biochemical pathways to flavor compounds and flavor notes. Taking semi\u2010hard and hard cheeses as examples, this review describes how cheese flavor profiles are affected by milk type and applied treatment, fat and salt content, microbiota composition and microbial interactions, ripening time, temperature, and environmental humidity, together with packaging method and material. Moreover, these factors are linked to flavor profiles through their effects on proteolysis, the further catabolism of amino acids, and lipolysis. Acids, alcohols, ketones, esters, aldehydes, lactones, and sulfur compounds are key volatiles, which elicit fruity, sweet, rancid, green, creamy, pungent, alcoholic, nutty, fatty, and sweaty flavor notes, contributing to the overall flavor profiles. Additionally, this review demonstrates how data\u2010driven modeling techniques can link these influencing factors to resulting flavor profiles. This is done by providing a comprehensive review on the (i) identification of key factors and flavor compounds, (ii) discrimination of cheeses, and (iii) prediction of flavor notes. Overall, this review provides knowledge tools for cheese flavor modulation and sheds light on using data\u2010driven modeling techniques to aid cheese flavor analysis and flavor prediction.<\/jats:p>","DOI":"10.1111\/1541-4337.13420","type":"journal-article","created":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T09:54:27Z","timestamp":1725184467000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Tuning and modeling cheese flavor"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9786-0976","authenticated-orcid":false,"given":"Huabin","family":"Luo","sequence":"first","affiliation":[{"name":"BioTeC+, Chemical and Biochemical Process Technology and Control, Department of Chemical Engineering KU Leuven  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2904-0439","authenticated-orcid":false,"given":"Simen","family":"Akkermans","sequence":"additional","affiliation":[{"name":"BioTeC+, Chemical and Biochemical Process Technology and Control, Department of Chemical Engineering KU Leuven  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5222-1313","authenticated-orcid":false,"given":"Davy","family":"Verheyen","sequence":"additional","affiliation":[{"name":"BioTeC+, Chemical and Biochemical Process Technology and Control, Department of Chemical Engineering KU Leuven  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2113-7415","authenticated-orcid":false,"given":"Jian","family":"Wang","sequence":"additional","affiliation":[{"name":"BioTeC+, Chemical and Biochemical Process Technology and Control, Department of Chemical Engineering KU Leuven  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1138-5618","authenticated-orcid":false,"given":"Monika","family":"Polanska","sequence":"additional","affiliation":[{"name":"BioTeC+, Chemical and Biochemical Process Technology and Control, Department of Chemical Engineering KU Leuven  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan F. 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