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Methanol is neurotoxic, and its metabolites of formaldehyde and formic acid can cause organic lesions and central respiratory system disorders. FFWs with unspecified methanol limits are often produced with reference to grape wine standards (250\/400\u00a0mg\/L). To clarify the causes of methanol production in FFWs and minimize the methanol content, this study summarizes the current process methods commonly applied for methanol reduction in FFWs and proposes novel potential controlling strategies from the perspective of raw materials (pectin, pectinase, and yeast), which are mainly the low esterification modification and removal of pectin, passivation of the pectinase activity, and the gene editing of yeast to target the secretion of pectinases and modulation of the glycine metabolic pathway. The modified raw materials combined with optimized fermentation processes will hopefully be able to improve the current situation of high methanol content in FFWs. Methanol detection technologies have been outlined and combined with machine learning that will potentially guide the production of low\u2010methanol FFWs and the setting of methanol limits for specific FFW.<\/jats:p>","DOI":"10.1111\/1541-4337.70048","type":"journal-article","created":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T11:55:41Z","timestamp":1730721341000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Controlling strategies of methanol generation in fermented fruit wine: Pathways, advances, and applications"],"prefix":"10.1111","volume":"23","author":[{"given":"Ju","family":"Shen","sequence":"first","affiliation":[{"name":"College of Food Science and Nutritional Engineering, Beijing Key Laboratory of Viticulture and Enology China Agricultural University  Beijing 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