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The aim of this comprehensive review was to synthesize and evaluate the latest research on furan, from its formation by different precursors to its presence in diverse food matrices, as well as the emerging methods for its detection and mitigation. Emphasizing the toxicity of furan, it explored evidence from in vitro and in vivo studies, including reproductive toxicity, carcinogenic effects, and related biomarkers. Additionally, this review focused on human risk assessments of furan exposure and discussed innovative research approaches to better understand its health risks. By consolidating current knowledge, this review provided a comprehensive perspective on furan's impact on human health and suggested future research directions to further research on furan.<\/jats:p>","DOI":"10.1111\/1541-4337.70087","type":"journal-article","created":{"date-parts":[[2024,12,28]],"date-time":"2024-12-28T12:04:54Z","timestamp":1735387494000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Demystifying furan formation in foods: Implications for human health, detection, and control measures: A review"],"prefix":"10.1111","volume":"24","author":[{"given":"Zahra","family":"Batool","sequence":"first","affiliation":[{"name":"Center of High Altitude Medicine and Institutes for Systems Genetics, Frontiers Science Center for Disease\u2010related Molecular Network, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3353-7897","authenticated-orcid":false,"given":"Rajeev K.","family":"Singla","sequence":"additional","affiliation":[{"name":"Center of High Altitude Medicine and Institutes for Systems Genetics, Frontiers Science Center for Disease\u2010related Molecular Network, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Amjad","family":"Kamal","sequence":"additional","affiliation":[{"name":"Center of High Altitude Medicine and Institutes for Systems Genetics, Frontiers Science Center for Disease\u2010related Molecular Network, West China Hospital Sichuan University  Chengdu China"},{"name":"King Fahd Medical Research Center King Abdulaziz University  Jeddah Saudi Arabia"},{"name":"Enzymoics Novel Global Community Educational Foundation  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bairong","family":"Shen","sequence":"additional","affiliation":[{"name":"Center of High Altitude Medicine and Institutes for Systems Genetics, Frontiers Science Center for Disease\u2010related Molecular Network, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,28]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodcont.2020.107233"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods11162453"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/19440049.2016.1278080"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxres\/tfad025"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.3c01352"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00217\u2010020\u201003556\u20102"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13197\u2010020\u201004760\u20104"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2020.1734532"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10529\u2010021\u201003205\u2010y"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfca.2016.01.006"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/02772248.2013.796785"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.0c04140"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2022.132823"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/19393210.2014.981601"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods13132127"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crfs.2023.100673"},{"key":"e_1_2_12_18_1","first-page":"155","volume-title":"Breathborne biomarkers and the human volatilome","author":"Christopher A. 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