{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T10:20:25Z","timestamp":1779272425133,"version":"3.51.4"},"reference-count":106,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T00:00:00Z","timestamp":1738627200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ift.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Comp Rev Food Sci Food Safe"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Humans are exposed to a complex mixture of environmental and food\u2010related chemicals throughout their lifetime. Exposome research intends to explore the nongenetic, that is, environmental causes of chronic disease and their interactions comprehensively. Residual antibiotics can enter the human body through therapeutics, foods of animal origin, aquatic products, or drinking water. In the last decade, significant levels of residual antibiotics in human urine have been described, demonstrating frequent exposure throughout populations. To which extent they contribute to human health risks is debated. Human biomonitoring (HBM) aims to determine and quantify concentrations of xenobiotics in human specimens and provides the toolbox to monitor exposure to diverse chemical exposures. Due to their public health implications, priority\u2010listed xenobiotics are routinely monitored in the European Union and other countries. However, antibiotics, an important class of (food\u2010derived) xenobiotics, are still not systematically investigated for a better and more holistic understanding in the context of exposomics. This review provides a comprehensive summary of HBM research related to antibiotics, existing liquid chromatography\u2013mass spectrometry (LC\u2013MS)\u2010based analytical methods, and potential health risks caused by unintended exposure. Incorporating antibiotics into the chemical exposome framework through routine HBM using multiclass analytical methods will provide a better understanding of the toxicological or pharmacological mixture effects and, ultimately, the chemical exposome.<\/jats:p>","DOI":"10.1111\/1541-4337.70105","type":"journal-article","created":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T09:00:26Z","timestamp":1738659626000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The role of residual (veterinary) antibiotics in chemical exposome analysis: Current progress and future perspectives"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8740-9532","authenticated-orcid":false,"given":"Md Zakir","family":"Hossain","sequence":"first","affiliation":[{"name":"Faculty of Chemistry, Department of Food Chemistry and Toxicology University of Vienna  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9839-0542","authenticated-orcid":false,"given":"Max L.","family":"Feuerstein","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry, Department of Food Chemistry and Toxicology University of Vienna  Vienna Austria"},{"name":"Exposome Austria, Research Infrastructure and National EIRENE Node  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6104-0706","authenticated-orcid":false,"given":"Benedikt","family":"Warth","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry, Department of Food Chemistry and Toxicology University of Vienna  Vienna Austria"},{"name":"Exposome Austria, Research Infrastructure and National EIRENE Node  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,2,4]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2017.06.014"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2022.05.008"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2014.1539"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2018.12.015"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11306\u2010016\u20101061\u20102"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s42452\u2010020\u201003742\u20107"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2019.112904"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad9358"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2021.132226"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2012.09.016"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.200600536"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2014.11.034"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2012.06.022"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2016.06.025"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.4155\/bio.15.121"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2012.10.046"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2015.06.038"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2008.01.037"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356\u2010017\u20109306\u20109"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.2903\/sp.efsa.2024.EN\u20108669"},{"key":"e_1_2_13_22_1","first-page":"1","article-title":"Commission Regulation (EU) No 37\/2010 of 22 December 2009 on pharmacologically active substances and their classification regarding maximum residue limits in foodstuffs of animal origin","volume":"15","author":"European Union (EU)","year":"2010","journal-title":"Official Journal of the European Union"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/exposome\/osac008"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2010.01.031"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2017.12.039"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2021.106940"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.9b01016"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacsau.2c00433"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2023.341740"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2020.106164"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2021.112736"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2023.124687"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2023.117151"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00216\u2010024\u201005374\u2010x"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2022.154775"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2018.12.019"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0229205"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12302\u2010020\u201000444\u20100"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010022\u201030204\u2010y"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2013.07.024"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.microc.2009.10.010"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxrep.2015.11.009"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2012.12.028"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1093\/exposome\/osac002"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/dta.2104"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010pharmtox\u2010051922\u2010113350"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.4c01156"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2014.11.014"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00176\u201016"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2017.08.014"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10337\u2010020\u201003866\u20103"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2017.04.216"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356\u2010021\u201012560\u20102"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.1080\/03601234.2021.2017211"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2007.01.001"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.15m09961"},{"key":"e_1_2_13_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2018.09.039"},{"key":"e_1_2_13_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2010.05.027"},{"key":"e_1_2_13_59_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015\u20102696"},{"key":"e_1_2_13_60_1","doi-asserted-by":"publisher","DOI":"10.1093\/exposome\/osab002"},{"key":"e_1_2_13_61_1","doi-asserted-by":"publisher","DOI":"10.1177\/14690667211003196"},{"key":"e_1_2_13_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2013.218"},{"key":"e_1_2_13_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2024.108766"},{"key":"e_1_2_13_64_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010food\u2010062220\u2010090807"},{"key":"e_1_2_13_65_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25112556"},{"key":"e_1_2_13_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.microc.2022.107309"},{"key":"e_1_2_13_67_1","doi-asserted-by":"publisher","DOI":"10.15386\/mpr\u20101742"},{"key":"e_1_2_13_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2020.09.012"},{"key":"e_1_2_13_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2014.04.029"},{"key":"e_1_2_13_70_1","doi-asserted-by":"publisher","DOI":"10.4155\/bio\u20102018\u20100181"},{"key":"e_1_2_13_71_1","doi-asserted-by":"publisher","DOI":"10.3390\/jox11040009"},{"key":"e_1_2_13_72_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365521.2017.1386711"},{"key":"e_1_2_13_73_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aao1495"},{"key":"e_1_2_13_74_1","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.5092"},{"key":"e_1_2_13_75_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aay3164"},{"key":"e_1_2_13_76_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.4c01630"},{"key":"e_1_2_13_77_1","doi-asserted-by":"publisher","DOI":"10.1093\/exposome\/osab003"},{"key":"e_1_2_13_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodcont.2017.04.034"},{"key":"e_1_2_13_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2021.118167"},{"key":"e_1_2_13_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2018.09.032"},{"key":"e_1_2_13_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2016.02.005"},{"key":"e_1_2_13_82_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.5b05749"},{"key":"e_1_2_13_83_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.8b03979"},{"key":"e_1_2_13_84_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00216\u2010014\u20108197\u20106"},{"key":"e_1_2_13_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2019.121129"},{"key":"e_1_2_13_86_1","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/bkz034"},{"key":"e_1_2_13_87_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.201500071"},{"key":"e_1_2_13_88_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.8b03979"},{"key":"e_1_2_13_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2018.09.032"},{"key":"e_1_2_13_90_1","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/bkz034"},{"key":"e_1_2_13_91_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.7b02759"},{"key":"e_1_2_13_92_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055\u20109965.Epi\u201005\u20100456"},{"key":"e_1_2_13_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2014.11.011"},{"key":"e_1_2_13_94_1","unstructured":"World Economic Forum. (2023).Three\u2010quarters of antibiotics are used on animals. Here's why that's a major problem.https:\/\/www.weforum.org\/agenda\/2017\/11\/three\u2010quarters\u2010of\u2010antibiotics\u2010are\u2010used\u2010on\u2010animals\u2010heres\u2010why\u2010thats\u2010a\u2010major\u2010problem"},{"key":"e_1_2_13_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2021.114558"},{"key":"e_1_2_13_96_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf505254y"},{"key":"e_1_2_13_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2017.10.020"},{"key":"e_1_2_13_98_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00216\u2010018\u20101062\u20102"},{"key":"e_1_2_13_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2015.05.032"},{"key":"e_1_2_13_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2020.105638"},{"key":"e_1_2_13_101_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168\u2010018\u20100602\u20105"},{"key":"e_1_2_13_102_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10653\u2010021\u201000840\u20102"},{"key":"e_1_2_13_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2020.110237"},{"key":"e_1_2_13_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2021.132657"},{"key":"e_1_2_13_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2020.106280"},{"key":"e_1_2_13_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2021.110945"},{"key":"e_1_2_13_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2019.113311"}],"container-title":["Comprehensive Reviews in Food Science and Food Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ift.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1541-4337.70105","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:32:42Z","timestamp":1761863562000},"score":1,"resource":{"primary":{"URL":"https:\/\/ift.onlinelibrary.wiley.com\/doi\/10.1111\/1541-4337.70105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,4]]},"references-count":106,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1111\/1541-4337.70105"],"URL":"https:\/\/doi.org\/10.1111\/1541-4337.70105","archive":["Portico"],"relation":{},"ISSN":["1541-4337","1541-4337"],"issn-type":[{"value":"1541-4337","type":"print"},{"value":"1541-4337","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,4]]},"assertion":[{"value":"2024-09-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70105"}}