{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T17:32:25Z","timestamp":1793035945130,"version":"4.5.0"},"reference-count":99,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T00:00:00Z","timestamp":1753401600000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["ift.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Comp Rev Food Sci Food Safe"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Supercritical carbon dioxide (SC\u2010CO\n                    <jats:sub>2<\/jats:sub>\n                    ) fractionation has emerged as an environmentally friendly technique for selective separation of valuable food compounds in a wide range of industrial applications. This review emphasizes the importance of recent advancements and trends in SC\u2010CO\n                    <jats:sub>2<\/jats:sub>\n                    fractionation as an eco\u2010friendly technology by conducting a systematic analysis of SC\u2010CO\n                    <jats:sub>2<\/jats:sub>\n                    fractionation studies published between 2020 and 2024. This study grouped the SC\u2010CO\n                    <jats:sub>2<\/jats:sub>\n                    fractionation efforts into three primary strategies: sequential extraction, multistage fractionation, and selective extraction. Various raw materials have been identified as suitable for producing value\u2010added food products using the SC\u2010CO\n                    <jats:sub>2<\/jats:sub>\n                    fractionation strategies. These include agricultural byproducts like sea buckthorn pomace and spent coffee grounds, marine residues such as sardine waste, industrial byproducts like bioethanol lipids and vacuum petroleum residue, as well as botanical sources, including hemp residues and clary sage concrete. These materials were fractionated to recover a wide range of high\u2010value compounds, such as lipids, polyphenols, terpenes, carotenoids, and essential oils, highlighting the adaptability of SC\u2010CO\n                    <jats:sub>2<\/jats:sub>\n                    to complex and diverse matrices. The findings reveal some trends linking raw materials, targeted compounds, and fractionation strategies. For instance, multistage fractionation dominated the recovery of lipids and antioxidants, whereas selective extraction was preferred for terpenes, cannabinoids, proteins, and specific fatty acids. Sequential methods were commonly employed for bioactive compounds in complex systems. This separation method and product\u2010oriented approach provide insights into SC\u2010CO\n                    <jats:sub>2<\/jats:sub>\n                    \u2019s efficiency in isolating bioactive materials for food, nutraceutical, pharmaceutical, and environmental applications.\n                  <\/jats:p>","DOI":"10.1111\/1541-4337.70240","type":"journal-article","created":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T07:29:41Z","timestamp":1753428581000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Recent Advances in Eco\u2010Friendly Supercritical Carbon Dioxide Fractionation Techniques for Food Applications"],"prefix":"10.1111","volume":"24","author":[{"given":"Arda","family":"Tuhanioglu","sequence":"first","affiliation":[{"name":"Department of Food Science University of Arkansas  Fayetteville Arkansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1636-9681","authenticated-orcid":false,"given":"Ali","family":"Ubeyitogullari","sequence":"additional","affiliation":[{"name":"Department of Food Science University of Arkansas  Fayetteville Arkansas USA"},{"name":"Department of Biological and Agricultural Engineering University of Arkansas  Fayetteville Arkansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,25]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.4c04277"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tifs.2020.07.016"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ffj.3661"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3311\/PPch.12780"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbp.2020.05.005"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2004.03.058"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12393\u2010023\u201009343\u20105"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2020.104960"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biortech.2021.125862"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2017.12.018"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2019.104689"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1039\/d0cp04985a"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12870\u2010023\u201004283\u2010y"},{"key":"e_1_2_10_15_1","unstructured":"Cicci A. G.Iaquaniello andA.Mazzelli.2022. \u201cPatent Application Publication.\u201d US 2022\/0364015 Al."},{"key":"e_1_2_10_16_1","volume-title":"Transforming the Performance of Medicines Through Particle Engineering. Green Manufacturing","author":"CrystecPharma","year":"2024"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejlt.202200006"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13197\u2010019\u201004209\u20103"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11627\u2010020\u201010097\u20106"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2020.105093"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2020.104754"},{"key":"e_1_2_10_22_1","unstructured":"Dukes S. P. G.Ganzi T.Mallmann S.Hadjikytiacou J.Griffis andM.Ghafari.2024. \u201cWorld Intellectual Property Organization.\u201d WO 2024\/010617 A1."},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ces.2018.10.035"},{"key":"e_1_2_10_24_1","volume-title":"Food Safety. Consultation Process on Novel Food Status","author":"European Commission","year":"2024"},{"key":"e_1_2_10_25_1","volume-title":"Novel Food. What Is Novel Food?","author":"European Commission"},{"key":"e_1_2_10_26_1","volume-title":"Guidance for Food Business Operators on the Verification of the Status of a New Food Under the New Novel Foods Regulation (EU) 2015\/2283 (NFR)","author":"Food Supplements Europe","year":"2019"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbio.2024.104371"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/1541-4337.70017"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods13111713"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcou.2021.101503"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11094\u2010024\u201003050\u2010z"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seppur.2020.116781"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2024.139833"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22071186"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1080\/10937400701597766"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10086\u2010007\u20100896\u20106"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtice.2020.12.024"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2020.00082"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.36719\/1726\u20104685\/95\/498\u2010504"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2022.115395"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ces.2024.120978"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2023.105903"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s43450\u2010021\u201000173\u20102"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2020.104943"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10111681"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2023.105937"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.3390\/en17051129"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.3390\/en13071600"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2022.860157"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22179351"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2019.104680"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2025.121348"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.procbio.2022.07.002"},{"key":"e_1_2_10_54_1","unstructured":"Official Journal of the European Union.2015.\u201cConsolidated Text: Regulation (EU) 2015\/2283 of the European Parliament and of the Council of 25 November 2015 on Novel Foods.\u201dOfficial Journal of the European Union November 25.https:\/\/eur\u2010lex.europa.eu\/legal\u2010content\/EN\/TXT\/?uri=CELEX%3A02015R2283\u201020210327."},{"key":"e_1_2_10_55_1","unstructured":"Official Journal of the European Union.2023. \u201cRegulation (Eu) 2023\/1115 of the European Parliament and of the Council of 31 May 2023 on the Making Available on the Union Market and the Export From the Union of Certain Commodities and Products Associated With Deforestation and Forest Degradation and Repealing Regulation (EU) No 995\/2010.\u201dOfficial Journal of the European Union May 31."},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2004.05.011"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics13111928"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2022.105565"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.3390\/app142310785"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/ceat.202300090"},{"key":"e_1_2_10_61_1","volume-title":"A supercritical CO2 GMP Unit for Pharmaceutical Applications. Drug Delivery Enhancement of API Using Supercritical CO2","author":"Pierre Fabre","year":"2025"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2022.115268"},{"key":"e_1_2_10_63_1","volume-title":"Supercritical Carbon Dioxide Extracts Market. How Do Regional Regulatory Frameworks Impact Market Accessibility for Supercritical CO\u2082 Extracts?","author":"Pmarketresearch","year":"2025"},{"key":"e_1_2_10_64_1","volume-title":"Botanical Co2 Extract Market. How Do Regional Regulatory Frameworks Impact the Production and Distribution of Botanical CO2 Extracts Globally?","author":"Pmarketresearch","year":"2025"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lwt.2020.109315"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26092774"},{"key":"e_1_2_10_67_1","volume-title":"Physical Methods in Chemistry and Nano Science","author":"Raja P. M. V.","year":"2024"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcou.2020.101359"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1039\/d3ra07426a"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.63125\/n6esv923"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1002\/ffj.3835"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2021.130159"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11157\u2010023\u201009669\u2010w"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym14122367"},{"key":"e_1_2_10_75_1","volume-title":"Advances in Neurotoxicology","author":"Skalny A. V.","year":"2021"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2005.08.028"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2020.104884"},{"key":"e_1_2_10_78_1","volume-title":"CO2 Extraction & Purification","author":"TharProcess","year":"2021"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.3390\/pr11041063"},{"key":"e_1_2_10_80_1","unstructured":"Trambitas D. O. F.Sotoodeh andG. F.Woerlee.2022. \u201cPatent Application Publication.\u201d US 2022\/0257521 Al."},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.polymer.2007.08.004"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fufo.2023.100253"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2023.106059"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsfoodscitech.2c00266"},{"key":"e_1_2_10_85_1","volume-title":"Food Ingredients & Packaging. Generally Recognized as Safe (GRAS)","author":"U.S. Food and Drug Administration (FDA)","year":"2023"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010019\u201055619\u20104"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcou.2023.102565"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.1039\/d0fo02271c"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2020.104898"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2019.104659"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfoodeng.2023.111846"},{"key":"e_1_2_10_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2015.07.002"},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbp.2016.01.004"},{"key":"e_1_2_10_94_1","doi-asserted-by":"publisher","DOI":"10.1063\/5.0215567"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.3390\/plants13162295"},{"key":"e_1_2_10_96_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.0c00724"},{"key":"e_1_2_10_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbio.2022.102270"},{"key":"e_1_2_10_98_1","doi-asserted-by":"publisher","DOI":"10.3390\/separations"},{"key":"e_1_2_10_99_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28093903"},{"key":"e_1_2_10_100_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jced.0c00175"}],"container-title":["Comprehensive Reviews in Food Science and Food Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ift.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1541-4337.70240","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ift.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1541-4337.70240","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ift.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1541-4337.70240","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T09:11:31Z","timestamp":1772961091000},"score":1,"resource":{"primary":{"URL":"https:\/\/ift.onlinelibrary.wiley.com\/doi\/10.1111\/1541-4337.70240"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":99,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1111\/1541-4337.70240"],"URL":"https:\/\/doi.org\/10.1111\/1541-4337.70240","archive":["Portico"],"relation":{},"ISSN":["1541-4337","1541-4337"],"issn-type":[{"value":"1541-4337","type":"print"},{"value":"1541-4337","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"2025-03-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70240"}}