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Colorimetric sensors, known for their rapid response, high sensitivity, low cost, and readily observable results, are playing an increasingly important role in food quality inspection. This review article provides an in\u2010depth discussion on the development and application of colorimetric sensing technology in the field of food detection and safety. The review outlines the fundamental principles of colorimetric sensors and provides a critical assessment of research on array dyes, substrates, and system optimization. In recent years, the optimization of functionalized precious metal nanoparticles and nanoenzymes has pushed detection limits down to the parts per billion level. Porous polymer substrates modified with synergistic flexible materials combine high adsorption, strong anti\u2010interference, and excellent mechanical properties, providing support for integrated applications in wearable sensors and smart packaging. The integration of data acquisition and analysis techniques based on color changes is also discussed. Through an overview of the application of sensors in food safety testing, food quality control, and food production and processing monitoring, this review article highlights the significant potential of colorimetric sensor arrays (CSAs) in enhancing food safety and quality. The review also identifies current challenges, with major obstacles including environmental interference, matrix effects, and limited industrial validation. The review concludes that combining advanced sensor materials, portable and stable optical devices with online analytical platforms for real\u2010time data extraction and simple analysis will enable CSAs to develop into a powerful on\u2010site tool for ensuring food quality and safety.<\/jats:p>","DOI":"10.1111\/1541-4337.70344","type":"journal-article","created":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T04:00:32Z","timestamp":1764561632000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Integration of Colorimetric Sensing Dyes and Multi\u2010Substrate Arrays for Food Quality and Safety Monitoring: Design, Optimization, and Analysis"],"prefix":"10.1111","volume":"25","author":[{"given":"Jingfei","family":"Shen","sequence":"first","affiliation":[{"name":"State Key Laboratory of Tea Plant Germplasm Innovation and Resource Utilization Anhui Agricultural University  Hefei 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