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However, dietary sulfites have been linked to adverse reactions in sensitive individuals, especially those with asthma. The International Organization of Vine and Wine (OIV) adopted the OENO 09\/1998 Resolution, which sets maximum sulfite limits according to wine types. It also recommends labeling when sulfite concentration exceeds 10\u00a0mg L\n                    <jats:sup>\u22121<\/jats:sup>\n                    , the threshold above which adverse effects may occur in sensitive individuals. Current analytical methods for sulfite quantification in wine lack precision at low concentration levels (typically below 10\u00a0mg L\n                    <jats:sup>\u22121<\/jats:sup>\n                    ). As an example, the official aeration\u2010oxidation (AO) method, also known as the Monier\u2010Williams method or the Frantz\u2010Paul method, even presents an error margin of approximately 10\u00a0mg L\n                    <jats:sup>\u22121<\/jats:sup>\n                    , making the accurate determination of sulfites in wine a significant challenge.\n                  <\/jats:p>\n                  <jats:p>\n                    A comprehensive overview of the main analytical methods developed for sulfite quantification in wine is discussed, highlighting both those currently applied in the wine industry and more innovative approaches that have been explored primarily in the scientific literature. The review also includes a preliminary section on sulfite chemistry, which is essential for a better understanding of the behavior of corresponding compounds, including free and bound SO\n                    <jats:sub>2<\/jats:sub>\n                    species, within the complex matrix of wine.\n                  <\/jats:p>\n                  <jats:p>The rise of new methods that are more accurate, rapid, easy\u2010to\u2010use, cost\u2010effective, and environmentally friendly presents valuable opportunities to enhance and optimize current sulfite management practices in winemaking. However, further development, validation, and standardization are still required before these new methods can be implemented in practice and commercialized.<\/jats:p>","DOI":"10.1111\/1541-4337.70396","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T14:57:06Z","timestamp":1772981826000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Sulfites Chemistry in Wines: From Reference Quantification Methods to More Sustainable Innovative Approaches"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-0846-3518","authenticated-orcid":false,"given":"Marion","family":"No\u00ebl","sequence":"first","affiliation":[{"name":"Universit\u00e9 Bourgogne Europe, Institut Agro, INRAE UMR PAM  Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9600-7467","authenticated-orcid":false,"given":"Laura","family":"Carballido","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Bourgogne Europe, Institut Agro, INRAE UMR PAM  Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0208-858X","authenticated-orcid":false,"given":"Elias","family":"Bou\u2010Maroun","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Bourgogne Europe, Institut Agro, INRAE UMR PAM  Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4229-3003","authenticated-orcid":false,"given":"Thomas","family":"Karbowiak","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Bourgogne Europe, Institut Agro, INRAE UMR PAM  Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/19440049.2012.743191"},{"key":"e_1_2_9_3_1","unstructured":"Alpes Contr\u00f4le Certification.2019.Guide Des Exigences En Agriculture Biologique."},{"key":"e_1_2_9_4_1","first-page":"14","article-title":"Ionic Chromatographie Determination of Sulfites in Foods","volume":"69","author":"Anderson C.","year":"1986","journal-title":"Journal of Association of Official Analytical Chemists"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.snb.2022.131549"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2023.463936"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac086051c"},{"key":"e_1_2_9_8_1","unstructured":"Bioletti F. 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