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Here, programmable mass transfer is defined as the deliberate control of time\u2010 and space\u2010dependent fluxes through four main levers: active loading and speciation, carrier affinity, layer thickness and placement, and package geometry with boundary conditions. Relative to reviews published in the past 3 years that mainly organize the field by material class, active function, or broad sustainability trends, this paper contributes an integrated design framework built around state\u2010dependent mobility and partition maps, right\u2010sized dosing from target concentration\u2013time trajectories, transferability criteria for model calibration, and a retort practicality window based on barrier recovery and active kinetics at 0\u00a0h, 24\u00a0h, and 7 days. 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