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High\u2010pressure homogenization (HPH) has emerged as a scalable and environmentally sustainable method for developing structured delivery systems within food matrices. In HPH, fluid dispersions are driven through a narrow homogenization valve at extremely high pressure, creating intense shear stress, turbulence, cavitation, and droplet\u2010collision forces. These physico\u2010mechanical processes significantly reduce the droplet size, redesign interfacial properties, and facilitate the formation of kinetically stable emulsions and nanodelivery systems for efficient encapsulation and protection of BCs. This review critically examines recent progress in HPH\u2010assisted encapsulation technologies for food applications. It addresses the mechanisms underlying the formation and functional performance of nanoemulsions (NEs), solid lipid nanoparticles (SLNPs), and nanostructured lipid carriers (NLCs) generated via HPH. The discussion focuses on structure\u2013function relationships, physicochemical stability, encapsulation efficiency, and the integration of HPH with both thermal and nonthermal processing methods. HPH modifies biopolymer structures, improves interfacial properties, and facilitates the creation of stable nanoscale carriers with enhanced oxidative stability, controlled release profiles, and thermal protection for sensitive compounds. The combination of HPH with complementary processing techniques further influences structural transitions and functional outcomes. Although laboratory\u2010scale results are promising, challenges persist regarding scalability, long\u2010term stability, and industrial adoption. In summary, HPH\u2010based encapsulation offers a robust platform for developing next\u2010generation functional foods, fostering innovation in product design and value\u2010added applications.<\/jats:p>","DOI":"10.1111\/1541-4337.70596","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T12:03:21Z","timestamp":1786536201000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["High\u2010Pressure Homogenization (HPH)\u2010Based Bioactive\u2010Loaded Nanocarriers in the Food Industry: Principles, Applications, and Challenges"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2001-1036","authenticated-orcid":false,"given":"Usman","family":"Majeed","sequence":"first","affiliation":[{"name":"College of Food Science and Engineering Central South University of Forestry and Technology  Changsha 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