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Melon seeds, as a major by\u2010product of the melon processing industry, are estimated to have an annual recyclable volume of approximately 738,000 tons. They are often discarded, causing resource waste and environmental pressure. Due to its well\u2010balanced amino acid profile, melon seed proteins are regarded as a valuable source of nontraditional proteins. Building upon and extending previous foundational studies, this review systematically integrates current knowledge on melon seed proteins across multiple species, with emphasis on varietal differences, protein compositional, amino acid composition, and emerging extraction techniques. It also systematically introduces the functional characteristics of melon seed proteins and their wide applications in the conventional food matrices and emerging food systems. In addition, the key challenges limiting industrial translation and potential strategies, including lower technofunctional properties relative to conventional proteins, inherent antinutritional factors, and economic hurdles in large\u2011scale extraction and modification are also discussed. Melon seed proteins exhibit species\u2010dependent nutritional advantages and favorable functional attributes, positioning them as promising complementary ingredients to conventional plant proteins. The development and utilization of melon seed proteins can effectively transform agricultural waste into health\u2010promoting food ingredients.<\/jats:p>","DOI":"10.1111\/1541-4337.70606","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:33:32Z","timestamp":1787024012000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Melon Seed Proteins: From Waste to Wellness\u2014Functionality and Opportunities in Future Foods"],"prefix":"10.1111","volume":"25","author":[{"given":"Jincan","family":"Wu","sequence":"first","affiliation":[{"name":"College of Food Science and Engineering Tianjin University of Science &amp; Technology  Tianjin City PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Food and Biological Engineering Bengbu University  Bengbu Anhui Province PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zexu","family":"Li","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering Tianjin University of Science &amp; Technology  Tianjin City PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinjie","family":"Shang","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering Tianjin University of Science &amp; Technology  Tianjin City PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyu","family":"Lin","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering Tianjin University of Science &amp; Technology  Tianjin City PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Li","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering Tianjin University of Science &amp; Technology  Tianjin City PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaohui","family":"Xu","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering Tianjin University of Science &amp; Technology  Tianjin City PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7281-7672","authenticated-orcid":false,"given":"Rui","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering Tianjin University of Science &amp; 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