{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T11:02:32Z","timestamp":1790247752597,"version":"4.1.0"},"reference-count":151,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["ift.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Comp Rev Food Sci Food Safe"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Selenium nanoparticles (SeNPs) are increasingly recognized as promising nanozymes for food safety because they combine enzyme\u2010mimetic catalytic activity, broad\u2010spectrum antimicrobial effects, and relatively favorable biocompatibility. However, current understanding remains fragmented across materials science, microbiology, and food application research, and a critical synthesis focused on their food\u2010system relevance is still lacking. This review examines how surface engineering and photoactivation are transforming SeNPs from general antimicrobial nanomaterials into multifunctional platforms for food\u2010related use. We summarize recent advances in their photodynamic and photocatalytic properties, antibacterial and antibiofilm activities, mechanistic basis, and applications in food packaging, food\u2010processing environments, and biosensing. Recent studies show that ligand design plays a central role in determining colloidal stability, bacterial affinity, visible\u2010light responsiveness, catalytic efficiency, and sensing capability. Mechanistically, Se nanozymes act not only through oxidase\u2010like catalysis and reactive oxygen species generation, but also through membrane disruption, metabolic collapse, extracellular DNA degradation, quorum\u2010sensing interference, and, in advanced systems, ferroptosis\u2010like lipid peroxidation. These developments have expanded the potential of SeNPs from microbial control and biofilm eradication to food preservation, process\u2010water disinfection, contaminant removal, and rapid detection of food\u2010relevant analytes. Key challenges remain in standardizing synthesis, clarifying structure\u2010activity relationships, validating performance in real food matrices, and establishing long\u2010term safety, recovery, and regulatory feasibility. A more mechanism\u2010oriented and application\u2010driven framework will be essential for translating Se nanozymes into robust and sustainable food safety technologies.<\/jats:p>","DOI":"10.1111\/1541-4337.70609","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:34:31Z","timestamp":1787024071000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Surface\u2010Engineered Selenium Nanozymes for Food Safety: Photoregulated Catalysis, Multimodal Antibacterial Mechanisms, and Emerging Applications in Food Processing, Packaging, and Biosensing"],"prefix":"10.1111","volume":"25","author":[{"given":"An\u2010qi","family":"Wang","sequence":"first","affiliation":[{"name":"School of Food Science and Biotechnology Zhejiang Gongshang University  Hangzhou Zhejiang China"},{"name":"Institute of Food Microbiology Zhejiang Gongshang University  Hangzhou Zhejiang 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