{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T11:03:05Z","timestamp":1790247785704,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T00:00:00Z","timestamp":1787443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T00:00:00Z","timestamp":1787443200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["ift.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Comp Rev Food Sci Food Safe"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Vegetables anchor healthy\u2010diet recommendations yet are the principal nonoccupational route by which residues of organophosphate (OP), pyrethroid, neonicotinoid, organochlorine (OC), and glyphosate herbicide enter the diet, with the gut microbiota a plausible mediator linking these residues to functional gastrointestinal (GI) and inflammatory bowel outcomes. We conducted a scoping review following the PRISMA extension for Scoping Reviews (PRISMA\u2010ScR), searching PubMed (2010 to April 2026) with mandatory backward and forward citation tracing for human studies of dietary or biomarker\u2010confirmed pesticide exposure against gut microbiota, intestinal barrier and inflammation, functional GI disorders, or inflammatory bowel disease (IBD). Risk of bias (RoB) was appraised with ROBINS\u2010E and Cochrane RoB 2.0, and evidence was synthesized in a 60\u2010cell pesticide\u2010class \u00d7 outcome gap matrix. Twenty\u2010eight papers were retained; 20 full\u2010text\u2010extracted human studies entered the synthesis, populating 20 of 60 cells (33%). The strongest convergent within\u2010scope signal was OC exposure \u00d7 IBD, where three cohorts agreed in direction (hazard ratios 1.56\u20131.61; Faroese risk ratio 3.04 on 37 cases). As a microbiota\u2010mediation exemplar for an adjacent non\u2010GI endpoint, the MCMC Nanjing pregnancy cohort linked a pesticide environmental risk score to gestational diabetes (adjusted odds ratio 4.5; 95% CI, 1.4\u201313.8; internal\u2010validation area under the curve 0.83), with a\n                    <jats:italic>Dorea<\/jats:italic>\n                    \u2010branch microbiota mediating part of the path. Glyphosate \u00d7 IBD and neonicotinoid \u00d7 any GI outcome remained empty. RoB centered on Moderate (11 of 22 rated cohorts), with six elevated\u2010bias contributors. Biomarker\u2010anchored prospective cohorts targeting the empty cells should be the next research priority.\n                  <\/jats:p>","DOI":"10.1111\/1541-4337.70622","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T03:38:00Z","timestamp":1787542680000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pesticide Residues, Gut Microbiota, and Gastrointestinal Outcomes: A Scoping Review of Human Evidence"],"prefix":"10.1111","volume":"25","author":[{"given":"Chengqian","family":"Ye","sequence":"first","affiliation":[{"name":"Department of Gastroenterology The Affiliated People's Hospital of Fujian University of Traditional Chinese Medicine  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingjie","family":"Wu","sequence":"additional","affiliation":[{"name":"Research Base of Traditional Chinese Medicine Syndrome Fujian University of Traditional Chinese Medicine  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaochu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Anorectal Surgery The Affiliated People's Hospital of Fujian University of Traditional Chinese Medicine  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7206-7813","authenticated-orcid":false,"given":"Cai","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Health and Kinesiology University of Illinois Urbana\u2010Champaign  Urbana Illinois USA"},{"name":"Beckman Institute for Advanced Science and Technology University of Illinois Urbana\u2010Champaign  Urbana Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,23]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2024.118710"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/jaoac\/86.2.412"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/1364557032000119616"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1408660"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2024.118464"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2024.174475"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2017.08.027"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2019.104957"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2024.170483"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2025.138465"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.2903\/j.efsa.2025.9398"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2020.109898"},{"key":"e_1_2_14_14_1","doi-asserted-by":"crossref","unstructured":"Fathi M. 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