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This review critically evaluates fractionation technologies through the lens of the \u201cpurity\u2010yield\u2010sustainability\u201d trilemma. First\u2010generation chemical precipitation methods achieve high purity at the laboratory scale but suffer from heavy reagent use, environmental burden, and poor scalability. Second\u2010generation green and physical techniques, such as phytase\u2010assisted, membrane\u2010based, and field\u2010assisted separation, improve sustainability but face challenges in fouling control, process stability, and scale\u2010up. Third\u2010generation upstream strategies, including breeding and gene editing, fundamentally alter the 7S\/11S ratio at the source, potentially bypassing downstream tradeoffs. Functionally, 7S globulin excels in regulating lipid metabolism and reducing obesity and non\u2010alcoholic fatty liver disease, whereas 11S globulin shows advantages in blood pressure regulation and cardiovascular protection. Structurally, 7S exhibits favorable emulsification and foaming capacities, whereas 11S dominates gel network formation, supporting diverse applications from plant\u2010based foods to nanocarriers and biodegradable films. Future breakthroughs lie in AI\u2010guided hybrid separation systems, data\u2010driven process optimization, and direct linking of fractionation outcomes to end\u2010use functionality. Moving beyond mixed utilization toward precision deployment, soybean 7S and 11S globulins can evolve from bulk commodities into high\u2010value resources for sustainable food systems and precision health applications.<\/jats:p>","DOI":"10.1111\/1541-4337.70626","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T08:04:54Z","timestamp":1787731494000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Beyond Mixed Utilization: Fractionation, Functional Divergence, and Precision Applications of Soybean 7S and 11S Globulins"],"prefix":"10.1111","volume":"25","author":[{"given":"Shunan","family":"Hu","sequence":"first","affiliation":[{"name":"Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences\/Key Laboratory of Agro\u2010Products Processing Ministry of Agriculture  Beijing China"},{"name":"Institute of Western Agriculture Chinese Academy of Agricultural 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