{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T17:12:00Z","timestamp":1761844320561,"version":"build-2065373602"},"reference-count":46,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T00:00:00Z","timestamp":1393632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T00:00:00Z","timestamp":1393632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","jognn.awhonn.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Obstetric, Gynecologic &amp; Neonatal Nursing"],"published-print":{"date-parts":[[2014,3]]},"DOI":"10.1111\/1552-6909.12282","type":"journal-article","created":{"date-parts":[[2014,2,6]],"date-time":"2014-02-06T10:45:08Z","timestamp":1391683508000},"page":"226-235","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Hormone Therapy for the Management of Menopause Symptoms"],"prefix":"10.1016","volume":"43","author":[{"given":"Heidi Collins","family":"Fantasia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa A.","family":"Sutherland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"14","key":"10.1111\/1552-6909.12282_bb0010","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1001\/jama.291.14.1701","article-title":"Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: The Women's Health Initiative randomized controlled trial","volume":"291","author":"Anderson","year":"2004","journal-title":"Journal of the American Medical Association"},{"issue":"5","key":"10.1111\/1552-6909.12282_bb0015","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1097\/gme.0b013e3181a3cdaf","article-title":"Change in health\u2010related quality of life over the menopausal transition in a multiethnic cohort of middle\u2010aged women: Study of women's health across the nation (SWAN)","volume":"16","author":"Avis","year":"2009","journal-title":"Menopause: The Journal of the North American Menopause Society"},{"key":"10.1111\/1552-6909.12282_bb0020","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1097\/01.AOG.0000284450.51264.31","article-title":"Lowest effective transdermal 17beta\u2010estradiol dose for relief of hot flushes in postmenopausal women: A randomized controlled trial","volume":"110","author":"Bachmann","year":"2007","journal-title":"Obstetrics and Gynecology"},{"issue":"1","key":"10.1111\/1552-6909.12282_bb0025","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1097\/gme.0b013e3181b20b2d","article-title":"Daily vasomotor symptoms, sleep problems, and mood: Using daily data to evaluate the domino hypothesis in middle\u2010aged women","volume":"17","author":"Burleson","year":"2010","journal-title":"Menopause: The Journal of the North American Menopause Society"},{"issue":"1","key":"10.1111\/1552-6909.12282_bb0030","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0378-5122(00)00091-8","article-title":"Acute effects of estradiol and progesterone on insulin, lipids and lipoproteins in postmenopausal women: A pilot study","volume":"35","author":"Cheung","year":"2000","journal-title":"Maturitas"},{"key":"10.1111\/1552-6909.12282_bb0035","first-page":"e023","article-title":"A critique of Women's Health Initiative studies (2002\u20132006)","volume":"4","author":"Clark","year":"2006","journal-title":"Nuclear Receptor Signaling"},{"issue":"3","key":"10.1111\/1552-6909.12282_bb0040","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1097\/01.AOG.0000137833.43248.79","article-title":"Effects of ultralow\u2010dose transdermal estradiol on bone mineral density: A randomized clinical trial","volume":"104","author":"Ettinger","year":"2004","journal-title":"Obstetrics &Gynecology"},{"year":"2010","series-title":"Consumer health information\/U.S. Food and Drug Administration, July 2010","key":"10.1111\/1552-6909.12282_bb0045"},{"issue":"2","key":"10.1111\/1552-6909.12282_bb0050","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1089\/jwh.2011.2839","article-title":"Are all estrogens created equal? A review of oral vs. transdermal therapy","volume":"21","author":"Goodman","year":"2012","journal-title":"Journal of Women's Health"},{"issue":"6","key":"10.1111\/1552-6909.12282_bb0055","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1097\/gme.0b013e31824f5cbb","article-title":"Effects of estrogen on vaginal innervation: Denervation or remodeling?","volume":"19","author":"Gorodeski","year":"2012","journal-title":"Menopause: The Journal of the North American Menopause Society"},{"issue":"2","key":"10.1111\/1552-6909.12282_bb0060","doi-asserted-by":"crossref","first-page":"105","DOI":"10.3109\/13697137.2011.650656","article-title":"Executive summary of the Stages of Reproductive Aging Workshop+10: Addressing the unfinished agenda of staging reproductive aging","volume":"15","author":"Harlow","year":"2012","journal-title":"Climacteric"},{"issue":"3","key":"10.1111\/1552-6909.12282_bb0065","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.amjmed.2010.09.021","article-title":"Timing and duration of menopausal hormone treatment may affect cardiovascular outcomes","volume":"124","author":"Harman","year":"2011","journal-title":"American Journal of Medicine"},{"key":"10.1111\/1552-6909.12282_bb0070","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1001\/jama.291.1.47","article-title":"National use of post\u2010menopausal hormone therapy: Annual trends and response to recent evidence","volume":"291","author":"Hersh","year":"2004","journal-title":"Journal of the American Medical Association"},{"key":"10.1111\/1552-6909.12282_bb0075","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1007\/s11136-011-9959-7","article-title":"The impact of menopause on health\u2010related quality of life: Results from the STRIDE longitudinal study","volume":"21","author":"Hess","year":"2012","journal-title":"Quality of Life Research"},{"issue":"6","key":"10.1111\/1552-6909.12282_bb0080","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1097\/01.GME.0000064865.58809.3E","article-title":"Severity of menopausal symptoms and use of both conventional and complementary\/alternative therapies","volume":"10","author":"Keenan","year":"2003","journal-title":"Menopause: The Journal of the North American Menopause Society"},{"issue":"3","key":"10.1111\/1552-6909.12282_bb0085","first-page":"1","article-title":"Deaths: Final data for 2009","volume":"60","author":"Kochanek","year":"2011","journal-title":"National Vital Statistics Reports"},{"key":"10.1111\/1552-6909.12282_bb0090","doi-asserted-by":"crossref","first-page":"193","DOI":"10.2147\/DDDT.S4146","article-title":"Transdermal hormone therapy in postmenopausal women: A review of metabolic effects and drug delivery technologies","volume":"2","author":"Kopper","year":"2008","journal-title":"Drug Design, Development, and Therapy"},{"issue":"4","key":"10.1111\/1552-6909.12282_bb0095","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1097\/01.AOG.0000140688.71638.d3","article-title":"Phytoestrogens for treatment of menopausal symptoms: A systematic review","volume":"104","author":"Krebs","year":"2004","journal-title":"Obstetrics & Gynecology"},{"issue":"10","key":"10.1111\/1552-6909.12282_bb0100","first-page":"1","article-title":"Does the route of administration for estrogen hormone therapy impact the risk of venous thromboembolism? Estradiol transdermal system versus oral estrogen\u2010only hormone therapy","volume":"18","author":"Laliberte","year":"2011","journal-title":"Menopause: The Journal of the North American Menopause Society"},{"key":"10.1111\/1552-6909.12282_bb0105","first-page":"CD001395","article-title":"Phytoestrogens for vasomotor menopausal symptoms","volume":"12","author":"Lethaby","year":"2007","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1111\/1552-6909.12282_bb0110","first-page":"853","article-title":"Bleeding patterns of the hormone replacement therapies in the postmenopausal estrogen and progestin interventions trial","volume":"100","author":"Linderfield","year":"2002","journal-title":"Obstetrics and Gynecology"},{"key":"10.1111\/1552-6909.12282_bb0115","first-page":"311","article-title":"Considerations in the choice of oral vs. transdermal hormone therapy: A review","volume":"49","author":"Minkin","year":"2004","journal-title":"Journal of Reproductive Medicine"},{"key":"10.1111\/1552-6909.12282_bb0120","first-page":"16","article-title":"Transdermal estrogen therapy: Personalized treatment approaches","volume":"35","author":"Minkin","year":"2010","journal-title":"The Female Patient"},{"issue":"1","key":"10.1111\/1552-6909.12282_bb0125","first-page":"1","article-title":"NIH state\u2010of\u2010the\u2010science conference statement on management of menopause\u2010related symptoms","volume":"22","year":"2005","journal-title":"NIH Consensus and State\u2010of\u2010the\u2010Science Statements"},{"key":"10.1111\/1552-6909.12282_bb0130","first-page":"36","article-title":"Hormone therapy in 2011: Rethinking the evidence","author":"Neal\u2010Perry","year":"2011","journal-title":"Contemporary OB\/GYN"},{"issue":"2","key":"10.1111\/1552-6909.12282_bb0135","doi-asserted-by":"crossref","first-page":"104","DOI":"10.7326\/0003-4819-157-2-201207170-00466","article-title":"Menopausal hormone therapy for the primary prevention of chronic conditions: A systematic review to update the U.S. Preventative Services Task Force recommendations","volume":"157","author":"Nelson","year":"2012","journal-title":"Annals of Internal Medicine"},{"issue":"4","key":"10.1111\/1552-6909.12282_bb0140","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1097\/gme.0b013e3181d2ce57","article-title":"Hormone therapy discontinuation: Physician practices after the Women's Health Initiative","volume":"17","author":"Newton","year":"2010","journal-title":"Menopause: The Journal of the North American Menopause Society"},{"key":"10.1111\/1552-6909.12282_bb0145","doi-asserted-by":"crossref","first-page":"869","DOI":"10.7326\/0003-4819-145-12-200612190-00003","article-title":"Treatment of vasomotor symptoms of menopause with black cohosh, multibiotanicals, soy, hormone therapy, or placebo","volume":"145","author":"Newton","year":"2006","journal-title":"Annals of Internal Medicine"},{"year":"2010","series-title":"Menopause practice: A clinician's guide","key":"10.1111\/1552-6909.12282_bb0150"},{"issue":"3","key":"10.1111\/1552-6909.12282_bb0155","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1097\/gme.0b013e31824b970a","article-title":"The 2012 hormone therapy position statement of the North American Menopause Society","volume":"19","year":"2012","journal-title":"Menopause: The Journal of the North American Menopause Society"},{"issue":"8","key":"10.1111\/1552-6909.12282_bb0160","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1001\/jama.290.8.1042","article-title":"Ultralow\u2010dose micronized 17 beta\u2010estradiol and bone density and bone metabolism in older women: A randomized controlled trial","volume":"290","author":"Prestwood","year":"2003","journal-title":"Journal of the American Medical Association"},{"issue":"3","key":"10.1111\/1552-6909.12282_bb0165","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.ogrm.2011.12.006","article-title":"The pathophysiology of menopausal symptoms","volume":"22","author":"O'Neill","year":"2012","journal-title":"Obstetrics, Gynaecology, and Reproductive Medicine"},{"issue":"1","key":"10.1111\/1552-6909.12282_bb0170","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1097\/gme.0b013e318057787f","article-title":"Vaginal, endometrial, and reproductive hormone findings: Randomized, placebo\u2010controlled trial of black cohosh, multibotanical herbs, and dietary soy for vasomotor symptoms: The Herbal Alternatives for Menopause (HALT) Study","volume":"15","author":"Reed","year":"2008","journal-title":"Menopause: The Journal of the North American Menopause Society"},{"issue":"3","key":"10.1111\/1552-6909.12282_bb0175","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.jmhg.2005.06.006","article-title":"Unraveling the confusion about HRT in women","volume":"2","author":"Rees","year":"2005","journal-title":"Journal of Men's Health and Gender"},{"issue":"3","key":"10.1111\/1552-6909.12282_bb0180","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1001\/jama.288.3.321","article-title":"Risks and benefits of estrogen plus progestin in healthy postmenopausal women: Principal results from the Women's Health Initiative randomized controlled trial","volume":"288","author":"Rossouw","year":"2002","journal-title":"Journal of the American Medical Association"},{"issue":"1","key":"10.1111\/1552-6909.12282_bb0185","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1097\/AOG.0b013e31827a08c8","article-title":"Lessons learned from the women's health initiative trials of menopausal hormone therapy","volume":"121","author":"Rossouw","year":"2013","journal-title":"Obstetrics & Gynecology"},{"issue":"13","key":"10.1111\/1552-6909.12282_bb0190","first-page":"1465","article-title":"Postmenopausal hormone therapy and risk of cardiovascular disease by age and years since menopause","volume":"297","author":"Rossouw","year":"2007","journal-title":"Journal of the American Medical Association"},{"issue":"7 Supp 1","key":"10.1111\/1552-6909.12282_bb0195","first-page":"s1","article-title":"Postmenopausal hormone therapy: An Endocrine Society scientific statement","volume":"95","author":"Santen","year":"2010","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1111\/1552-6909.12282_bb0200","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1097\/AOG.0b013e3181d41191","article-title":"Role of hormone therapy in the management of menopause","volume":"115","author":"Shifren","year":"2010","journal-title":"Obstetrics and Gynecology"},{"key":"10.1111\/1552-6909.12282_bb0205","first-page":"500","article-title":"Estrogen replacement therapy for the treatment of postmenopausal genitourinary tract dysfunction","volume":"10","author":"Smith","year":"2010","journal-title":"Discovery Medicine"},{"issue":"4","key":"10.1111\/1552-6909.12282_bb0210","first-page":"823","article-title":"Efficacy and tolerability of a novel estradiol vaginal ring for relief of menopausal symptoms","volume":"102","author":"Speroff","year":"2003","journal-title":"Obstetrics & Gynecology"},{"issue":"3","key":"10.1111\/1552-6909.12282_bb0215","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1097\/gme.0b013e3181f0839a","article-title":"Age\u2010specific effects of hormone therapy use on overall mortality and ischemic heart disease mortality among women in the California Teachers Study","volume":"18","author":"Stram","year":"2011","journal-title":"Menopause: The Journal of the North American Menopause Society"},{"key":"10.1111\/1552-6909.12282_bb0220","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.1744-4667.2012.00143.x","article-title":"Nonpharmacological treatment of postmenopausal symptoms","volume":"15","author":"Tong","year":"2013","journal-title":"The Obstetrician & Gynaecologist"},{"year":"2010","series-title":"Profile of general population and housing characteristics: 2010 demographic profile data","key":"10.1111\/1552-6909.12282_bb0225"},{"key":"10.1111\/1552-6909.12282_bb0230","doi-asserted-by":"crossref","first-page":"320","DOI":"10.3109\/13697137.2012.678916","article-title":"A decade post WHI, menopausal hormone therapy comes full circle\u2010need for independent commission","volume":"15","author":"Utian","year":"2012","journal-title":"Climacteric"},{"year":"1996","series-title":"Research on menopause in the 1990s","key":"10.1111\/1552-6909.12282_bb0235"}],"container-title":["Journal of Obstetric, Gynecologic &amp; Neonatal Nursing"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0884217515315239?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0884217515315239?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:02:43Z","timestamp":1760126563000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0884217515315239"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3]]},"references-count":46,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["S0884217515315239"],"URL":"https:\/\/doi.org\/10.1111\/1552-6909.12282","relation":{},"ISSN":["0884-2175"],"issn-type":[{"type":"print","value":"0884-2175"}],"subject":[],"published":{"date-parts":[[2014,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hormone Therapy for the Management of Menopause Symptoms","name":"articletitle","label":"Article Title"},{"value":"Journal of Obstetric, Gynecologic & Neonatal Nursing","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1111\/1552-6909.12282","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 AWHONN, the Association of Women's Health, Obstetric and Neonatal Nurses. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}