{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:35:35Z","timestamp":1761708935250},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,10,22]],"date-time":"2013-10-22T00:00:00Z","timestamp":1382400000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Forensic Sciences"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Three separate cases of child administration of prescription drugs are described. Following liquid\u2013liquid extraction, high\u2010performance liquid chromatography\u2013tandem mass spectrometry (<jats:styled-content style=\"fixed-case\">HPLC<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>) was used to identify and quantify methadone, 2\u2010ethylidene\u20101,5\u2010dimethyl\u20103,3\u2010diphenyl\u20101\u2010pyrrolidine (<jats:styled-content style=\"fixed-case\">EDDP<\/jats:styled-content>), tramadol, amitriptyline, and nortriptyline in children's hair. The children's age ranged from 14 months to 7\u00a0years; in all three cases, the drug in question was detected in more than one section of hair. Methadone was detected in the concentration range of 0.65\u20130.99 and 0.04\u20130.4\u00a0ng\/mg; tramadol was detected in the concentration range of 1.5\u20132.2\u00a0ng\/mg; amitriptyline and nortriptyline were detected in the concentration range of 0.18\u20131.06 and 0.38\u20132.0\u00a0ng\/mg, respectively. In each case, the children's parents admitted to or were found guilty of drug administration to the child. These cases demonstrate the added value of hair testing and emphasize the importance of using hair samples to complement conventional analyses.<\/jats:p>","DOI":"10.1111\/1556-4029.12301","type":"journal-article","created":{"date-parts":[[2013,10,22]],"date-time":"2013-10-22T16:13:23Z","timestamp":1382458403000},"page":"281-286","source":"Crossref","is-referenced-by-count":18,"title":["Interpretation of Pharmaceutical Drug Concentrations in Young Children's Head Hair"],"prefix":"10.1111","volume":"59","author":[{"given":"Craig","family":"Chatterton","sequence":"first","affiliation":[{"name":"Office of the Chief Medical Examiner 7007\u2010116 Street NW Edmonton AB T6H 5R8 Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirsten","family":"Turner","sequence":"additional","affiliation":[{"name":"Laboratoire ChemTox 3 rue Gruninger Illkirch F\u201067400 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadine","family":"Klinger","sequence":"additional","affiliation":[{"name":"Laboratoire ChemTox 3 rue Gruninger Illkirch F\u201067400 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthieu","family":"Etter","sequence":"additional","affiliation":[{"name":"Laboratoire ChemTox 3 rue Gruninger Illkirch F\u201067400 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathieu","family":"Duez","sequence":"additional","affiliation":[{"name":"Laboratoire ChemTox 3 rue Gruninger Illkirch F\u201067400 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Cirimele","sequence":"additional","affiliation":[{"name":"Laboratoire ChemTox 3 rue Gruninger Illkirch F\u201067400 France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,10,22]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007691-200208000-00001"},{"issue":"2","key":"e_1_2_5_3_1","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1542\/peds.48.2.173","article-title":"Methadone and children","volume":"48","author":"Blatman S","year":"1971","journal-title":"Pediatrics"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.308.6940.1335"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.53.4.277"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/1353-1131(95)90082-9"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(82)80115-7"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2009.12.033"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/4.5.232"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(80)90657-2"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1191\/0960327105ht542oa"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0379-0738(99)00118-8"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0379-0738(93)90256-A"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/fn.88.2.F98"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1385\/FSMP:1:2:097"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/27.1.20"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0379-0738(03)00196-8"},{"key":"e_1_2_5_18_1","volume-title":"TIAFT 2001 Prague: programme and abstracts","author":"Eysseric H","year":"2001"},{"key":"e_1_2_5_19_1","unstructured":"MartinM TurnerK ValletE DuezM CirimeleV.Tramadol concentrations in human hair. 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