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Cardiac blood, femoral blood, muscle, and brain tissue concentrations of the enantiomers of methadone and its metabolite 2\u2010ethyl\u20101,5\u2010dimethyl\u20103,3\u2010diphenylpyrrolinium were recorded for 155 postmortem cases. Brain and muscle tissue concentrations exceeded the femoral blood concentrations with a median fold of 2.3 and 1.6, respectively, but both had a better correlation than cardiac blood to femoral blood concentrations. The Kruskal\u2013Wallis test showed a significant dependency on time and body mass index for some of the matrix ratios over femoral blood. We conclude brain or muscle tissue may constitute a better alternative for measurement of methadone than cardiac blood for situations in which femoral blood is not available, despite concentrations in both matrices being systematically higher.<\/jats:p>","DOI":"10.1111\/1556-4029.12627","type":"journal-article","created":{"date-parts":[[2014,11,24]],"date-time":"2014-11-24T18:05:47Z","timestamp":1416852347000},"page":"95-101","source":"Crossref","is-referenced-by-count":23,"title":["Distribution of Enantiomers of Methadone and Its Main Metabolite<scp>EDDP<\/scp>in Human Tissues and Blood of Postmortem Cases"],"prefix":"10.1111","volume":"60","author":[{"given":"Karen Marie Dollerup","family":"Holm","sequence":"first","affiliation":[{"name":"Section of Forensic Chemistry Department of Forensic Medicine Faculty of Health Sciences University of Copenhagen Frederik V's Vej 11 DK\u20102100 Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristian","family":"Linnet","sequence":"additional","affiliation":[{"name":"Section of Forensic Chemistry Department of Forensic Medicine Faculty of Health Sciences University of Copenhagen Frederik V's Vej 11 DK\u20102100 Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,11,24]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200241140-00003"},{"issue":"2","key":"e_1_2_5_3_1","doi-asserted-by":"crossref","first-page":"PL45","DOI":"10.1016\/0024-3205(94)00937-6","article-title":"The mu1, mu2, delta, kappa opioid receptor binding profiles of methadone stereoisomers and morphine","volume":"56","author":"Kristensen K","year":"1994","journal-title":"Life Sci"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/32.7.499"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2008.04.019"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2013.07.001"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12024-010-9150-4"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/27.8.533"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.2009.02111.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/29.4.223"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02340830"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.53.4.277"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2007.03.032"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168-0102(85)90035-5"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0376-8716(76)90020-X"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/dta.303"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/bks057"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7158.1971.tb09926.x"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1520\/JFS12828J"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1520\/JFS10344J"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1520\/JFS11751J"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2013.01.038"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/bkr013"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01225230"},{"key":"e_1_2_5_25_1","unstructured":"ReiterB.Rapid determination of methadone in postmortem whole blood and cerebellum. 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