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The objective of the study was to assess driving with and without <jats:styled-content style=\"fixed-case\">DXM<\/jats:styled-content> ingestion. The effects of one\u2010time maximum daily doses of <jats:styled-content style=\"fixed-case\">DXM<\/jats:styled-content> 120\u00a0mg versus a guaifenesin 400\u00a0mg dose were compared among 40 healthy subjects using a crossover design. Subjects\u2019 ability to drive was assessed by their performance in a driving simulator (<jats:styled-content style=\"fixed-case\">STISIM<\/jats:styled-content><jats:sup>\u00ae<\/jats:sup> <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>rive driving simulator software) and by conducting a standardized field sobriety test (<jats:styled-content style=\"fixed-case\">SFST<\/jats:styled-content>) administered 1\u2010h postdrug administration. The one\u2010time dose of <jats:styled-content style=\"fixed-case\">DXM<\/jats:styled-content> 120\u00a0mg did not demonstrate driving impairment on the <jats:styled-content style=\"fixed-case\">STISIM<\/jats:styled-content><jats:sup>\u00ae<\/jats:sup> <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>rive driving simulator or increase <jats:styled-content style=\"fixed-case\">SFST<\/jats:styled-content> failures compared to guaifenesin 400\u00a0mg. Doses greater than the currently recommended maximum daily dose of 120\u00a0mg are necessary to perturb driving behavior.<\/jats:p>","DOI":"10.1111\/1556-4029.12833","type":"journal-article","created":{"date-parts":[[2015,8,21]],"date-time":"2015-08-21T06:29:42Z","timestamp":1440138582000},"page":"1258-1262","source":"Crossref","is-referenced-by-count":5,"title":["The Effects of Dextromethorphan on Driving Performance and the Standardized Field Sobriety Test"],"prefix":"10.1111","volume":"60","author":[{"given":"Paul J.","family":"Perry","sequence":"first","affiliation":[{"name":"Touro University California College of Pharmacy Vallejo CA 94592"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristian","family":"Fredriksen","sequence":"additional","affiliation":[{"name":"Touro University California College of Pharmacy Vallejo CA 94592"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Chew","sequence":"additional","affiliation":[{"name":"Touro University California College of Pharmacy Vallejo CA 94592"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric J.","family":"Ip","sequence":"additional","affiliation":[{"name":"Touro University California College of Pharmacy Vallejo CA 94592"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Lopes","sequence":"additional","affiliation":[{"name":"Touro University California College of Pharmacy Vallejo CA 94592"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shadi","family":"Doroudgar","sequence":"additional","affiliation":[{"name":"Touro University California College of Pharmacy Vallejo CA 94592"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelan","family":"Thomas","sequence":"additional","affiliation":[{"name":"Touro University California College of Pharmacy Vallejo CA 94592"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,8,21]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/09595230412331289482"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/000992280504400702"},{"key":"e_1_2_5_4_1","unstructured":"DOT\/NHTSA.Development of a standardized field sobriety test (SFST): appendix A standardized field sobriety testing;http:\/\/www.nhtsa.gov\/People\/injury\/alcohol\/SFST\/appendix_a.htm(accessed June 16 2014)."},{"key":"e_1_2_5_5_1","volume-title":"DWI detection and standardized field sobriety testing: student manual","author":"DOT\/NHTSA\/TSI","year":"1995"},{"key":"e_1_2_5_6_1","unstructured":"Micromedex 2.0.Guaifenesin truven health analytics 2012\u20132014;http:\/\/www-micromedexsolutions-com.proxy.lib.uiowa.edu\/micromedex2\/librarian\/ND_T\/evidencexpert\/ND_PR\/evidencexpert\/CS\/B3008B\/ND_AppProduct\/evidencexpert\/DUPLICATIONSHIELDSYNC\/62203D\/ND_PG\/evidencexpert\/ND_B\/evidencexpert\/ND_P\/evidencexpert\/PFActionId\/evidencexpert.DoIntegratedSearch?SearchTerm&#x003D;Guaifenesin%20(accessed June 16 2014)."},{"key":"e_1_2_5_7_1","doi-asserted-by":"crossref","unstructured":"StusterJ BurnsM.Validation of the standardized field sobriety test battery at BACs below 0.10 percent. 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