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In this work, a method for opium profiling based on the relative content of five principal and 14 minor opium alkaloids was developed and validated. <jats:styled-content style=\"fixed-case\">UPLC<\/jats:styled-content>\u2010Q\u2010<jats:styled-content style=\"fixed-case\">TOF<\/jats:styled-content> was adopted in alkaloid analysis for its high selectivity and sensitivity, which facilitated the sample preparation and testing. The authentic sample set consisted of 100 \u201cMyanmar\u201d and 45 \u201cAfghanistan\u201d opium seizures; based on the data set of the 19 alkaloid variables in them, a partial least squares discriminant analysis classification model was successfully achieved. Minor alkaloids were found to be vitally important for opium profiling, although combined use of both principal and minor alkaloids resulted in the best geographical classification result. The developed method realized a simple and accurate way to differentiate opium from Myanmar and Afghanistan, which may find wide application in forensic laboratories.<\/jats:p>","DOI":"10.1111\/1556-4029.13190","type":"journal-article","created":{"date-parts":[[2016,9,23]],"date-time":"2016-09-23T17:03:12Z","timestamp":1474650192000},"page":"1615-1621","source":"Crossref","is-referenced-by-count":12,"title":["Classification of Opium by <scp>UPLC<\/scp>\u2010Q\u2010<scp>TOF<\/scp> Analysis of Principal and Minor Alkaloids"],"prefix":"10.1111","volume":"61","author":[{"given":"Cuimei","family":"Liu","sequence":"first","affiliation":[{"name":"National Narcotics Laboratory Drug Intelligence and Forensic Center of the Ministry of Public Security Beijing 100193 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhendong","family":"Hua","sequence":"additional","affiliation":[{"name":"National Narcotics Laboratory Drug Intelligence and Forensic Center of the Ministry of Public Security Beijing 100193 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanping","family":"Bai","sequence":"additional","affiliation":[{"name":"National Narcotics Laboratory Drug Intelligence and Forensic Center of the Ministry of Public Security Beijing 100193 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,9,23]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"crossref","DOI":"10.18356\/bdf42380-en","volume-title":"World drug report 2014","author":"United Nations International Drug Control Programme","year":"2014"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.200500078"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/pca.2800050105"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2007.10.023"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2006.09.040"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9673(95)00670-2"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2008.03.011"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0379-0738(79)90138-5"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(00)94605-3"},{"key":"e_1_2_5_11_1","first-page":"4","volume-title":"Recommended methods for testing opium, morphine and heroin. 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