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In 57 cases, we studied drug concentration differences as follows: subclavian vein\u2010dissection\/clamping versus blind stick, femoral vein\u2010dissection\/clamping versus blind stick, right cardiac chamber, and popliteal vein\u2010dissection and clamping only. Cases were distributed in group #1 (all cases with both techniques), group #2 (dissection\/clamping), and group #3 (blind stick). Sampled drugs were diazepam, methadone, morphine, and their metabolites. To assess <jats:styled-content style=\"fixed-case\">PMR<\/jats:styled-content>, mean concentrations and ratios were calculated for each group. Time\u2010dependent variations of blood concentrations and ratios were also assessed. Results indicate that site, method, and time may influence postmortem distribution interpretation in different ways. Popliteal blood seems less subject to <jats:styled-content style=\"fixed-case\">PMR<\/jats:styled-content>. In conclusion, our study is the first to evaluate concurrently three main aspects of <jats:styled-content style=\"fixed-case\">PMR<\/jats:styled-content> and confirms that the popliteal vein may represent a site that is more resistant to the changes seen as a result of <jats:styled-content style=\"fixed-case\">PMR<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/1556-4029.13404","type":"journal-article","created":{"date-parts":[[2017,1,20]],"date-time":"2017-01-20T15:41:45Z","timestamp":1484926905000},"page":"1559-1574","source":"Crossref","is-referenced-by-count":26,"title":["Site\u2010, Technique\u2010, and Time\u2010Related Aspects of the Postmortem Redistribution of Diazepam, Methadone, Morphine, and their Metabolites: Interest of Popliteal Vein Blood Sampling"],"prefix":"10.1111","volume":"62","author":[{"given":"Eric","family":"Lemaire","sequence":"first","affiliation":[{"name":"Department of Pathology University Hospital \u2013 CHU Sart Tilman Domaine Universitaire du Sart Tilman \u2013 B.35 Li\u00e8ge B\u20104000 Belgium"},{"name":"Department of Forensic Medicine Medico\u2010legal Institute of the University of Li\u00e8ge Rue Dos\u2010Fanchon 37 B\u20104020 Li\u00e8ge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Michigan 300 N. 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