{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:24:12Z","timestamp":1791419052783,"version":"4.3.3"},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,2,7]],"date-time":"2017-02-07T00:00:00Z","timestamp":1486425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Forensic Sciences"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>An elevated serum tryptase concentration is considered a specific marker for systemic mast cell activation, a central feature of anaphylaxis. However, in some cases of acute cardiovascular death, high concentrations of serum tryptase are also observed. We compared the postmortem serum tryptase concentrations in 74 cases assigned to the following four groups: anaphylactic deaths (Group A, <jats:italic>n<\/jats:italic> = 20), acute cardiac deaths (Group <jats:styled-content style=\"fixed-case\">ACD<\/jats:styled-content>,<jats:italic> n<\/jats:italic> = 30), acute dissecting aneurysm ruptures (Group <jats:styled-content style=\"fixed-case\">ADA<\/jats:styled-content>,<jats:italic> n<\/jats:italic> = 10), and controls (Group C, <jats:italic>n<\/jats:italic> = 14). Additionally, the cutoff between Group A and the other groups was calculated using receiver\u2010operating characteristic (<jats:styled-content style=\"fixed-case\">ROC<\/jats:styled-content>) curve analysis. Tryptase concentrations were markedly elevated in Group A (<jats:italic>p<\/jats:italic> &lt; 0.001), Group <jats:styled-content style=\"fixed-case\">ACD<\/jats:styled-content> (<jats:italic>p<\/jats:italic> = 0.015), and Group <jats:styled-content style=\"fixed-case\">ADA<\/jats:styled-content> (<jats:italic>p<\/jats:italic> = 0.005). The optimal cutoff was 43 ng\/mL, the sensitivity was 90%, and the specificity was 98%. While elevated concentrations of tryptase were noted in practical autopsy cases, due attention should be paid to the differential diagnosis between anaphylactic and acute cardiovascular deaths.<\/jats:p>","DOI":"10.1111\/1556-4029.13420","type":"journal-article","created":{"date-parts":[[2017,2,7]],"date-time":"2017-02-07T06:36:42Z","timestamp":1486449402000},"page":"1336-1338","source":"Crossref","is-referenced-by-count":34,"title":["Postmortem Serum Tryptase Levels with Special Regard to Acute Cardiac Deaths"],"prefix":"10.1111","volume":"62","author":[{"given":"Ning","family":"Xiao","sequence":"first","affiliation":[{"name":"Department of Forensic Medicine Southern Medical University 1838# Guangzhou Avenue North Guangzhou China 510000"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong\u2010Ri","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine Southern Medical University 1838# Guangzhou Avenue North Guangzhou China 510000"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine Southern Medical University 1838# Guangzhou Avenue North Guangzhou China 510000"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Forensic Pathology Ministry of Public Security People's Republic of China Beijiaochangheng Road 3# Yuexiu District, Guangzhou China 510050"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan\u2010Geng","family":"Yu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Forensic Pathology Ministry of Public Security People's Republic of China Beijiaochangheng Road 3# Yuexiu District, Guangzhou China 510050"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui\u2010Jun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine Southern Medical University 1838# Guangzhou Avenue North Guangzhou China 510000"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,2,7]]},"reference":[{"issue":"22","key":"e_1_2_5_2_1","doi-asserted-by":"crossref","first-page":"11939","DOI":"10.1016\/S0021-9258(19)68496-6","article-title":"Tryptase from human pulmonary mast cells. 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