{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T11:32:13Z","timestamp":1761823933450},"reference-count":61,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,8,23]],"date-time":"2017-08-23T00:00:00Z","timestamp":1503446400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Forensic Sciences"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Deaths due to meningiomas are routinely diagnosed in clinical practice because this neoplasm tends to present with the typical progression of neurological deficits. On the other hand, sudden unexpected deaths due to meningiomas are rarely described in the literature. The study presents six fatal cases of previously undiagnosed intracranial meningiomas from the Cook County Medical Examiner's Office from 1998 to 2014. The most common explanation of the mechanism of sudden death due to intracranial neoplasms is a rapid increase in intracranial pressure produced by the mass effect of the neoplasm. Other mechanisms of death include acute intracranial and intratumoral hemorrhage, and benign neoplasms that grow in the vicinity of vital centers altering neural discharge in autonomic pathways leading to cardiac suppression or lethal arrhythmia. Forensic pathologists must keep in mind that sudden unexpected death caused by intracranial meningiomas, although extremely rare, may be encountered in the forensic setting.<\/jats:p>","DOI":"10.1111\/1556-4029.13626","type":"journal-article","created":{"date-parts":[[2017,8,23]],"date-time":"2017-08-23T19:20:04Z","timestamp":1503516004000},"page":"947-953","source":"Crossref","is-referenced-by-count":12,"title":["Sudden Unexpected Deaths Due to Intracranial Meningioma: Presentation of Six Fatal Cases, Review of the Literature, and A Discussion of the Mechanisms of Death"],"prefix":"10.1111","volume":"63","author":[{"given":"Lorenzo","family":"Gitto","sequence":"first","affiliation":[{"name":"Department of Anatomy, Histology, Forensic Medicine, &amp; Orthopedics Sapienza University Viale Regina Elena 336 00185 Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgio","family":"Bolino","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Histology, Forensic Medicine, &amp; Orthopedics Sapienza University Viale Regina Elena 336 00185 Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen J.","family":"Cina","sequence":"additional","affiliation":[{"name":"Forensic Pathology Consultant Cina and Cina Forensic Consulting PC, 4883 Valley Oak Drive Loveland CO"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,8,23]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"164","volume-title":"WHO classification of tumours of the central nervous system","author":"Perry A","year":"2007"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000188281.91351.B9"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nos218"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-015-1930-2"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-009-9938-9"},{"key":"e_1_2_6_7_1","doi-asserted-by":"crossref","first-page":"488","DOI":"10.3760\/cma.j.issn.0366-6999.20122874","article-title":"Histopathological classification and location of consecutively operated meningiomas at a single institution in China from 2001 to 2010","volume":"126","author":"Wang DJ","year":"2013","journal-title":"Chin Med J (Engl)"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.63.1.116"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(82)90552-X"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.4.11.837"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00312500"},{"key":"e_1_2_6_12_1","first-page":"150","article-title":"Sudden death due to undiagnosed intracranial meningioma: a case report","volume":"32","author":"Huh GY","year":"2008","journal-title":"Korean J Leg Med"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.7580\/kjlm.2013.37.4.208"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.3126\/njms.v3i1.10364"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAF.0000000000000161"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0317167100026184"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.3340\/jkns.2011.49.1.26"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2004.09.029"},{"key":"e_1_2_6_19_1","first-page":"453","article-title":"A study of the effects of clinicobiological factors upon the meningioma\u2010associated peritumoral edema formation","volume":"27","author":"Nam DH","year":"1998","journal-title":"J Korean Neurosurg Soc"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1021186401522"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2007.06.001"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01410973"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01411166"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-200111000-00003"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-200106000-00010"},{"issue":"4","key":"e_1_2_6_26_1","first-page":"21","article-title":"Could meningiomas at certain locations at the skull base have a higher incidence of post\u2010operative pseudomeningocele and consequent communicating hydrocephalus than others? 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