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The mean age of <jats:styled-content style=\"fixed-case\">MT<\/jats:styled-content> cases was 36.7 years, and 86.0% were male. Strenuous activity was reported in 12.9%. The most common witness observations were: collapse (60.3%), difficulty in breathing (36.2%), and hyperthermia (27.6%). <jats:styled-content style=\"fixed-case\">MT<\/jats:styled-content> cases had higher blood methamphetamine (0.54 vs. 0.11 mg\/L) and amphetamine (0.04 vs. 0.02 mg\/L) concentrations and lower likelihoods for opioids (12.5% vs. 80.9%), hypnosedatives (27.3 vs. 60.7%), antidepressants (14.8 vs. 29.8%), and antipsychotics (9.1 vs. 19.7%). <jats:styled-content style=\"fixed-case\">MT<\/jats:styled-content> cases had significantly heavier hearts than <jats:styled-content style=\"fixed-case\">MDT<\/jats:styled-content> cases (423.4 vs. 385.8 g) and were more likely to have cardiomegaly (37.1 vs. 20.4%) and replacement fibrosis (25.7 vs. 14.5%). The clinical picture was of a sudden cardiac event in a middle\u2010aged man with a high methamphetamine concentration. Cardiovascular signs of heavy methamphetamine use are frequently seen.<\/jats:p>","DOI":"10.1111\/1556-4029.13710","type":"journal-article","created":{"date-parts":[[2018,9,3]],"date-time":"2018-09-03T18:41:10Z","timestamp":1536000070000},"page":"1466-1471","source":"Crossref","is-referenced-by-count":28,"title":["Clinical and Autopsy Characteristics of Fatal Methamphetamine Toxicity in Australia"],"prefix":"10.1111","volume":"63","author":[{"given":"Shane","family":"Darke","sequence":"first","affiliation":[{"name":"National Drug&amp; Alcohol Research Centre University of New South Wales Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Duflou","sequence":"additional","affiliation":[{"name":"National Drug&amp; Alcohol Research Centre University of New South Wales Sydney NSW Australia"},{"name":"Sydney Medical School University of Sydney Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Lappin","sequence":"additional","affiliation":[{"name":"National Drug&amp; 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