{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:22:42Z","timestamp":1762507362174},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,3,30]],"date-time":"2018-03-30T00:00:00Z","timestamp":1522368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Forensic Sciences"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Despite advances in the diagnosis and treatment of congenital heart defects (<jats:styled-content style=\"fixed-case\">CHD<\/jats:styled-content>s), these defects are still an important cause of sudden, unexpected death in young children. This retrospective study identified 64 cases of <jats:styled-content style=\"fixed-case\">CHD<\/jats:styled-content>s presenting as a cause of sudden, unexpected death in a busy, urban Medical Examiner's Office pediatric population between 2006 and 2016. The majority of cases (52 of 64, 81%) were infants. Interestingly, 52% of cases were undiagnosed prior to autopsy. Ventricular septal defects and atrioventricular septal defects were the most common simple (14%) and complex (17%) malformations observed, respectively. In many cases, there were coexistent simple and\/or complex defects. Most of the cases diagnosed with <jats:styled-content style=\"fixed-case\">CHD<\/jats:styled-content> prior to autopsy (48%) had undergone some type of surgical repair. This study highlights the importance of considering undiagnosed <jats:styled-content style=\"fixed-case\">CHD<\/jats:styled-content>s as a cause of sudden, unexpected death, particularly in young children.<\/jats:p>","DOI":"10.1111\/1556-4029.13779","type":"journal-article","created":{"date-parts":[[2018,3,30]],"date-time":"2018-03-30T16:34:03Z","timestamp":1522427643000},"page":"1750-1755","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Undiagnosed Congenital Heart Defects as a Cause of Sudden, Unexpected Death in Children"],"prefix":"10.1111","volume":"63","author":[{"given":"Serenella","family":"Serinelli","sequence":"first","affiliation":[{"name":"Medical Examiner\u2019s Office, Department of Anatomy, Histology, Forensic Medicine and Orthopedics Sapienza\u2010University of Rome Rome 00185 Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ponni","family":"Arunkumar","sequence":"additional","affiliation":[{"name":"Cook County Medical Examiners\u2019 Office Chicago IL 60612"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"White","sequence":"additional","affiliation":[{"name":"Cook County Medical Examiners\u2019 Office Chicago IL 60612"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,3,30]]},"reference":[{"key":"e_1_2_5_2_1","unstructured":"https:\/\/www.cdc.gov\/ncbddd\/heartdefects\/data.html(accessed June 6 2017)."},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcl.2004.04.013"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-011-1525-3"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv478"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1556-4029.2011.01807.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1385\/1592596738"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-59745-127-7"},{"key":"e_1_2_5_9_1","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1007\/b138665","volume-title":"Post mortem technique handbook","author":"Sheaff MT","year":"2005"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.PAT.0000443450.04023.20"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000433-200112000-00015"},{"key":"e_1_2_5_12_1","first-page":"167","article-title":"Sudden cardiac death and congenital heart disease (CHD)","volume":"23","author":"Sheppard MN","year":"2012","journal-title":"Perspect Paediatr Cardiol"},{"key":"e_1_2_5_13_1","unstructured":"https:\/\/www.nhlbi.nih.gov\/health\/health-topics\/topics\/chd\/types(accessed June 7 2017)."},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/000992289103000708"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.947002"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13312-011-0011-3"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/fn.71.3.F179"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/fn.80.1.F49"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.162.10.969"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.2005.044495"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2006.tb02253.x"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-0803.2010.00418.x"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.14503\/THIJ-14-4256"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951115001171"},{"key":"e_1_2_5_25_1","unstructured":"http:\/\/emedicine.medscape.com\/article\/890196-overview#a4(accessed June 8 2017)."},{"key":"e_1_2_5_26_1","first-page":"435","volume-title":"Nadas\u2019 pediatric cardiology","author":"Fyler DC","year":"1992"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00795710"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.618124"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s100249900130"},{"issue":"1","key":"e_1_2_5_30_1","doi-asserted-by":"crossref","first-page":"A1","DOI":"10.1016\/S0031-3025(16)35347-8","article-title":"Ventricular septal defect and sudden paediatric death","volume":"27","author":"Byard RW","year":"1995","journal-title":"Pathology"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2008.10.001"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehm398"},{"issue":"1","key":"e_1_2_5_33_1","first-page":"S10","article-title":"Factors affecting mortality in Ebstein's anomaly of the tricuspid valve","volume":"82","author":"Khositseth A","year":"1999","journal-title":"J Med Assoc Thai"},{"key":"e_1_2_5_34_1","volume-title":"Ferri's clinical advisor e\u2010book","author":"Ferri FF","year":"2015"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2003.033027"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.162.10.969"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d6838"},{"issue":"5","key":"e_1_2_5_38_1","first-page":"491","article-title":"Analysis of mutations in 7 candidate genes for dextro\u2010transposition of the great arteries in Chinese population","volume":"6","author":"Lei L","year":"2014","journal-title":"J Thorac Dis"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2006.04.030"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2009.12.050"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1136\/heart.88.2.113"},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02714-8"},{"key":"e_1_2_5_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40556-015-0061-z"}],"container-title":["Journal of Forensic Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1556-4029.13779","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1556-4029.13779","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T02:42:29Z","timestamp":1694918549000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1556-4029.13779"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,30]]},"references-count":42,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["10.1111\/1556-4029.13779"],"URL":"https:\/\/doi.org\/10.1111\/1556-4029.13779","archive":["Portico"],"relation":{},"ISSN":["0022-1198","1556-4029"],"issn-type":[{"value":"0022-1198","type":"print"},{"value":"1556-4029","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,30]]},"assertion":[{"value":"2017-12-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-02-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-03-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}