{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T10:48:22Z","timestamp":1777718902210,"version":"3.51.4"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,9,19]],"date-time":"2018-09-19T00:00:00Z","timestamp":1537315200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007397","name":"Univerzita Karlova v Praze","doi-asserted-by":"publisher","award":["GAUK 598217"],"award-info":[{"award-number":["GAUK 598217"]}],"id":[{"id":"10.13039\/100007397","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Forensic Sciences"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Recreational use of the potent synthetic opioid <jats:italic>3,4\u2010<\/jats:italic> dichloro\u2010N\u2010(2\u2010(dimethylamino)cyclohexyl)\u2010N\u2010methylbenzamide (U\u201047700) is rising, accompanied by increasingly frequent cases of serious intoxication. This article reports a case of near\u2010fatal U\u201047700 intoxication. A man was found unconscious (with drug powder residues). After 40 h in hospital (including 12 h of supported ventilation), he recovered and was discharged. Liquid chromatography\/high\u2010resolution mass spectrometry (<jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">HRMS<\/jats:styled-content>) or gas chromatography\/mass spectrometry (<jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>) were used to detect and quantify substances in powders, serum and urine. Powders contained U\u201047700 and two synthetic cannabinoids. Serum and urine were positive for U\u201047700 (351.0 ng\/mL), citalopram (&lt;<jats:styled-content style=\"fixed-case\">LOQ<\/jats:styled-content>), tetrahydrocannabinol (<jats:styled-content style=\"fixed-case\">THC<\/jats:styled-content>: 3.3 ng\/mL), midazolam (&lt;<jats:styled-content style=\"fixed-case\">LOQ<\/jats:styled-content>) and a novel benzodiazepine, clonazolam (6.8 ng\/mL) and their metabolites but negative for synthetic cannabinoids. If potent synthetic opioids become cheaper and more easily obtainable than their classical counterparts (e.g., heroin), they will inevitably replace them and users may be exposed to elevated risks of addiction and overdose.<\/jats:p>","DOI":"10.1111\/1556-4029.13903","type":"journal-article","created":{"date-parts":[[2018,9,19]],"date-time":"2018-09-19T10:41:22Z","timestamp":1537353682000},"page":"647-650","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Near\u2010fatal Intoxication with the \u201cNew\u201d Synthetic Opioid U\u201047700: The First Reported Case in the Czech Republic"],"prefix":"10.1111","volume":"64","author":[{"given":"Monika","family":"\u017didkov\u00e1","sequence":"first","affiliation":[{"name":"Institute of Forensic Medicine and Toxicology First Faculty of Medicine Charles University and General University Hospital in Prague Ke Karlovu 2 121 08 Prague Czech 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904.1978."},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm00150a017"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2017.08.016"},{"key":"e_1_2_6_15_1","first-page":"658","volume-title":"Foye's principles of medicinal chemistry","author":"Williams DA","year":"2013"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2013.08.028"},{"issue":"10","key":"e_1_2_6_17_1","first-page":"e1791","article-title":"U\u201047700: an emerging threat","volume":"9","author":"Alzghari SK","year":"2017","journal-title":"Cureus"},{"issue":"3","key":"e_1_2_6_18_1","first-page":"173","article-title":"Analysis of U\u201047700, a novel synthetic opioid, in human urine by LC\u2010MSMS and LC\u2010QToF","volume":"41","author":"Fleming SW","year":"2017","journal-title":"J Anal 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