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Aliquots of seized drug materials from Kentucky (<jats:italic>n<\/jats:italic> = 200) and Vermont (<jats:italic>n<\/jats:italic> = 315) were prepared using a dilute\u2010and\u2010shoot procedure. Initial analysis was performed using gas chromatography\u2013mass spectrometry (GC\u2010MS) followed by analysis using liquid chromatography quadrupole time\u2010of\u2010flight mass spectrometry (LC\u2010QTOF). Active compounds detected overall included caffeine (31.0%), quinine\/quinidine (24.7%), levamisole (11.6%), acetaminophen, (8.2%) and procaine (8.2%). These compounds were found with several drugs of abuse, such as heroin, fentanyl, methamphetamine, and cocaine. This novel information about cutting agents used to dilute or alter drugs of abuse is important to criminal investigations and in the management of acute intoxications at health centers. However, common methodologies for analysis and standard reporting practices frequently do not include cutting agents, resulting in lacking or inadequate information regarding prevalence of these substances.<\/jats:p>","DOI":"10.1111\/1556-4029.13968","type":"journal-article","created":{"date-parts":[[2018,11,28]],"date-time":"2018-11-28T21:35:51Z","timestamp":1543440951000},"page":"888-896","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":84,"title":["Detection of Cutting Agents in Drug\u2010Positive Seized Exhibits within the United States"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5843-6443","authenticated-orcid":false,"given":"Ta\u00eds R.","family":"Fiorentin","sequence":"first","affiliation":[{"name":"The Center for Forensic Science Research and Education at the Fredric Rieders Family Foundation 2300 Stratford Ave Willow Grove PA 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