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The spectral profile analysis indicated that hypothermia fatalities associated with pulmonary edema fluid contained more \u03b2\u2010sheet protein conformational structures than the control causes of death, which included sudden cardiac death, brain injury, cerebrovascular disease, mechanical asphyxiation, intoxication, and drowning. Subsequently, the results of principal component analysis (PCA) further revealed that the content of \u03b2\u2010sheet protein conformational structures in the pulmonary edema fluid was the main discriminatory marker between fatal hypothermia and the other causes of death. Ultimately, a robust postmortem diagnostic model for fatal hypothermia using a partial least\u2010squares discriminant analysis (PLS\u2010DA) algorithm was constructed. Pulmonary edema fluid spectra collected from eight new forensic autopsy cases that did not participate in the construction of the diagnostic model were predicted using the model. The results showed the causes of death of all these eight cases were correctly classified. In conclusion, this preliminary study demonstrates that FTIR spectroscopy in combination with chemometrics could be a promising approach for the postmortem diagnosis of fatal hypothermia.<\/jats:p>","DOI":"10.1111\/1556-4029.14260","type":"journal-article","created":{"date-parts":[[2019,12,23]],"date-time":"2019-12-23T14:04:48Z","timestamp":1577109888000},"page":"846-854","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Postmortem Diagnosis of Fatal Hypothermia by Fourier Transform Infrared Spectroscopic Analysis of Edema Fluid in Formalin\u2010Fixed, Paraffin\u2010Embedded Lung Tissues"],"prefix":"10.1111","volume":"65","author":[{"given":"Hancheng","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Forensic Pathology Xi\u2019an Jiaotong University Xi\u2019an 710061 China"},{"name":"Shanghai Key Laboratory of Forensic Medicine Shanghai Forensic Service Platform Academy of Forensic Science 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