{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T04:29:24Z","timestamp":1789705764838,"version":"4.0.1"},"reference-count":14,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,1,10]],"date-time":"2020-01-10T00:00:00Z","timestamp":1578614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"13th Five-Year National Key Research & Development Program of China","award":["2018YFC0807202-3"],"award-info":[{"award-number":["2018YFC0807202-3"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Forensic Sciences"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Methyl nitrite is suggested to cause methemoglobinemia by generating methemoglobin, which may be lethal when the methemoglobin concentration exceeds 70%. However, intoxication with methyl nitrite is seldom reported compared with that with other nitrites. Here, we present an industrial accident involving methyl nitrite inhalation during its synthesis process that resulted in three fatalities and one survivor. The autopsy revealed conspicuous blue\u2010gray discoloration in various parts of the body, including the skin, airway mucosa, vessels, brain, heart, and among other areas. The toxicological tests on the deceased showed methemoglobin concentrations in the blood over the lethal level and increased nitrite ion levels in the blood, gastric contents, liver, and lung tissue compared with those in control samples. The cause of death was determined to be methemoglobinemia\u2010induced hypoxia due to methyl nitrite inhalation. This report provides evidence that in methyl nitrite intoxication, exposure duration has a significant influence on the postmortem changes and likelihood of a fatal outcome may be related to the age of the victim. More attention is required regarding the industrial hazards of this substance.<\/jats:p>","DOI":"10.1111\/1556-4029.14275","type":"journal-article","created":{"date-parts":[[2020,1,10]],"date-time":"2020-01-10T23:00:36Z","timestamp":1578697236000},"page":"1016-1022","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Fatal Methemoglobinemia Due to Acute Inhalation of Methyl Nitrite in an Industrial Accident"],"prefix":"10.1111","volume":"65","author":[{"given":"Sizhe","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Forensic Medicine Tongji Medical College Huazhong University of Science and Technology No. 13 Hangkong Road Wuhan 430030 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongshuai","family":"Wang","sequence":"additional","affiliation":[{"name":"Chongxin Judcial Expertise Center (Hubei) Wuhan 430415 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