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The stability of 4\u2010CMC was determined in postmortem blood samples (for a period of 90\u00a0days) and vitreous humor (30\u00a0days) at three different temperatures: \u221215\u00b0C, +4\u00b0C, and\u00a0+\u00a023\u00b0C. The analyses were carried out using ultra\u2010high\u2010performance liquid chromatography coupled with triple\u2010quadrupole tandem mass spectrometry (UHPLC\u2010QqQ\u2010MS\/MS). In both materials, the lowest 4\u2010CMC stability was demonstrated at room temperature. The blood samples stored in a freezer (\u221215\u00b0C) showed stability for the entire study period (90\u00a0days), while in the case of the vitreous humor sample stored at the same temperature the concentration of the substance decreased by 53% after 30\u00a0days. The study carried out in authentic postmortem blood and vitreous humor samples confirms the previous reports of 4\u2010CMC instability in biological material. Authors suggest that the biological material should be stored frozen until analyses are carried out as soon as possible after collection of the material.<\/jats:p>","DOI":"10.1111\/1556-4029.14454","type":"journal-article","created":{"date-parts":[[2020,5,14]],"date-time":"2020-05-14T19:15:34Z","timestamp":1589483734000},"page":"1784-1790","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["The Stability of 4\u2010Chloromethcathinone in Blood and Vitreous Humor"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0104-1053","authenticated-orcid":false,"given":"Karolina","family":"Nowak","sequence":"first","affiliation":[{"name":"Department of Forensic Medicine Wroclaw Medical University 4 J. 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Mikulicza\u2010Radeckiego Street 50\u2010345 Wroc\u0142aw Poland"},{"name":"Institute of Toxicology Research 45 Kasztanowa Street 55\u2010093 Borowa Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2018.12.001"},{"key":"e_1_2_7_3_1","unstructured":"World Health Organization.Critical review report: 4\u2010CMC (4\u2010chloromethcathinone).https:\/\/www.who.int\/medicines\/access\/controlled\u2010substances\/Final_4\u2010CMC.PDF?ua=1(accessed March 28 2020)."},{"key":"e_1_2_7_4_1","unstructured":"Dziennik Ustaw 2018 poz. 1591.Rozporz\u0105dzenie Ministra Zdrowia z dnia 17 sierpnia 2018 r. w sprawie wykazu substancji psychotropowych \u015brodk\u00f3w odurzaj\u0105cych oraz nowych substancjipsychoaktywnych [Journal of Laws of the Republic of Poland 2018 item 1591. 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