{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T02:48:54Z","timestamp":1790304534911,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,10,7]],"date-time":"2020-10-07T00:00:00Z","timestamp":1602028800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Forensic Sciences"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Testing for drugs in hair raises several difficulties. Among them is the interpretation of the final concentration(s). In a post\u2010mortem case, analyses revealed the presence of furosemide (12\u00a0ng\/mL) in femoral blood, although it was not part of the victim's treatment. The prosecutor requested our laboratory to undertake an additional analysis in hair to obtain information about the use of furosemide. A specific method was therefore developed and validated to identify and quantify furosemide in hair by UHPLC\u2010MS\/MS. After decontamination of 30\u00a0mg of hair, incubation in acidic condition, extraction with ethyl acetate, the samples were analyzed by UHPLC\u2010MS\/MS. Furosemide was found in the victim's hair at 225\u00a0pg\/mg. However, it was not possible to interpret this concentration due to the absence of data in the literature. Therefore, the authors performed a controlled study in two parts. In order to establish the basis of interpretation, several volunteers were tested (four after a single 20\u00a0mg administration and twenty\u2010four under daily treatment). The first part indicated that a single dose is not detectable in hair using our method. The second part demonstrated concentrations ranging from 5 to 1110\u00a0pg\/mg with no correlation between dosage and hair concentrations. The decedent's hair result was interpreted as repeated exposures. In the case of furosemide analysis, hair can provide information about its presence but cannot give information about dosage or frequency of use.<\/jats:p>","DOI":"10.1111\/1556-4029.14585","type":"journal-article","created":{"date-parts":[[2020,10,7]],"date-time":"2020-10-07T18:59:27Z","timestamp":1602097167000},"page":"272-277","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Identification of furosemide in hair in a post\u2010mortem case by UHPLC\u2010MS\/MS with guidance on interpretation"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7804-3946","authenticated-orcid":false,"given":"Laurie","family":"Gheddar","sequence":"first","affiliation":[{"name":"Institut de M\u00e9decine L\u00e9gale Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Odile","family":"Batt","sequence":"additional","affiliation":[{"name":"Centre hospitalier de Molsheim Molsheim France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9991-3795","authenticated-orcid":false,"given":"Jean\u2010S\u00e9bastien","family":"Raul","sequence":"additional","affiliation":[{"name":"Institut de M\u00e9decine L\u00e9gale Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4174-5362","authenticated-orcid":false,"given":"Pascal","family":"Kintz","sequence":"additional","affiliation":[{"name":"Institut de M\u00e9decine L\u00e9gale Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2019.02.036"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00414-018-1939-9"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2018.01.020"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2019.110137"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0025802418768305"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/dta.1607"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2019.02.030"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/dta.2713"},{"key":"e_1_2_6_10_1","first-page":"117","article-title":"Identification of 25I\u2010NBOMe in two intoxications cases with severe hallucinations","volume":"29","author":"Ameline A","year":"2017","journal-title":"Tox Anal Clin"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/dta.2445"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/dta.2555"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2011.10.024"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.201"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/js960268h"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2004.02.027"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2011.01.041"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1520\/JFS13766J"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00414-020-02267-3"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/20.3.197"}],"container-title":["Journal of Forensic Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1556-4029.14585","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1556-4029.14585","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1556-4029.14585","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T07:48:00Z","timestamp":1693727280000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1556-4029.14585"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,7]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1111\/1556-4029.14585"],"URL":"https:\/\/doi.org\/10.1111\/1556-4029.14585","archive":["Portico"],"relation":{},"ISSN":["0022-1198","1556-4029"],"issn-type":[{"value":"0022-1198","type":"print"},{"value":"1556-4029","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,7]]},"assertion":[{"value":"2020-06-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}