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In this study, we aimed at investigating the pharmaceutical drug and drug of abuse profiles of the deceased included in the Danish prospective autopsy\u2010based forensic study on psychiatric patients, SURVIVE. Using the postmortem systematic toxicological analysis results, we identified 129 different consumed compounds in our population (<jats:italic>n<\/jats:italic>\u00a0=\u00a0443). Polypharmacy (\u22655 compounds) was detected in 39.5% of the deceased. Deceased with a psychiatric diagnosis or who died from a fatal intoxication had significantly more compounds at the time of their death compared to having either no psychiatric diagnosis or another cause of death, respectively. Evidence of drug abuse was present, as 29.8% of our total population had consumed either methadone or illicit drugs of abuse, excluding tetrahydrocannabinol. Of those deceased with a psychiatric diagnosis, 33.6% had either consumed methadone or illicit drugs of abuse, a greater number than those without a psychiatric diagnosis. Fatal intoxication was the most frequent cause of death (40.6%) with methadone as the major intoxicant. Here, we found that those without a psychiatric diagnosis had fewer fatal pharmaceutical drug intoxications compared to the psychiatric diagnosis groups. Our findings add further context to understanding the excess mortality of psychiatric patents, since there is an increased occurrence of fatal intoxication, polypharmacy, and drug abuse in this population.<\/jats:p>","DOI":"10.1111\/1556-4029.14586","type":"journal-article","created":{"date-parts":[[2020,10,5]],"date-time":"2020-10-05T14:04:50Z","timestamp":1601906690000},"page":"255-264","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Increased risk of fatal intoxication and polypharmacy among psychiatric patients at death"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9477-0895","authenticated-orcid":false,"given":"Christian Fyhn","family":"Reuss","sequence":"first","affiliation":[{"name":"Section of Forensic Chemistry Department of Forensic Medicine Faculty of Health Aarhus University Aarhus N Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f8rgen Bo","family":"Hasselstr\u00f8m","sequence":"additional","affiliation":[{"name":"Section of Forensic Chemistry Department of Forensic Medicine Faculty of Health Aarhus University Aarhus N Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristian","family":"Linnet","sequence":"additional","affiliation":[{"name":"Section of Forensic Chemistry Department of Forensic Medicine Faculty of Health and Medicial Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorte Jensen","family":"Christoffersen","sequence":"additional","affiliation":[{"name":"Section of Forensic Chemistry Department of Forensic Medicine Faculty of Health Sciences University of Southern Denmark Odense C Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter Mygind","family":"Leth","sequence":"additional","affiliation":[{"name":"Section of Forensic Pathology Department of Forensic Medicine Faculty of Health Sciences University of Southern Denmark Odense C Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lene Warner Thorup","family":"Boel","sequence":"additional","affiliation":[{"name":"Section of Forensic Pathology Department of Forensic Medicine Faculty of Health Aarhus University Aarhus N Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jytte","family":"Banner","sequence":"additional","affiliation":[{"name":"Section of Forensic Pathology Department of Forensic Medicine Faculty of Health and Medicial Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,10,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2014.2502"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0055176"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.110.085100"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2010.02.1030"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/10673220600889256"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00127-007-0247-3"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2017.07.004"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/08039488.2017.1400098"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(15)00207-2"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.2478\/sjfs-2018-0002"},{"key":"e_1_2_7_12_1","unstructured":"Sundheds\u2010og \u00c6ldreministeriet [Ministry of Health].Bekendtg\u00f8relse om euforiserende stoffer [Act on psychoactive compounds].https:\/\/www.retsinformation.dk\/Forms\/R0710.aspx?id=137169. 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