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A series of aqueous fentanyl solutions were prepared with commercially available gold nanoparticle solution, at concentrations ranging from 0.003 to 1697\u00a0\u03bcM. These SERS spectra were then used to generate two concentration calibration models (via a plot of peak area (1026\u00a0cm<jats:sup>\u22121<\/jats:sup>) versus concentration, and quantitative spectral decomposition using partial least squares (PLS1)). For both models, the relationship followed Langmuir adsorption and became non\u2010linear at concentrations above ~0.2\u00a0\u03bcM, with a limit of detection (LOD) of approximately 3\u00a0nM. The same technique was successfully used to measure fentanyl in the presence of two common \u201ccutting agents,\u201d heroin and glucose, at 1% and 2% fentanyl proportions (w\/w). Fentanyl detection was successfully achieved, but mixture interference from the cutting agents prevented a calibration model being generated. Four fentanyl analogues were also investigated\u2014butyrylfentanyl, furanylfentanyl, acetylfentanyl, and ocfentanyl. A concentration calibration model for each species was successfully generated, but differentiation from fentanyl proved more challenging, although several potential diagnostic peaks were identified. These results identified a pathway forward in using handheld equipment for the reliable detection of ultra\u2010low concentrations of fentanyl and fentanyl analogues via SERS, even when mixed with diluents. However, quantitative detection is negatively impacted in the presence of heroin and glucose. This also provides a starting point for a SERS\u2010based spectral library of fentanyl analogues, in combination with a range of different diluents.<\/jats:p>","DOI":"10.1111\/1556-4029.14610","type":"journal-article","created":{"date-parts":[[2020,11,2]],"date-time":"2020-11-02T16:07:36Z","timestamp":1604333256000},"page":"505-519","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["A Semi\u2010quantitative method for the detection of fentanyl using surface\u2010enhanced Raman scattering (SERS) with a handheld Raman instrument"],"prefix":"10.1111","volume":"66","author":[{"given":"Matthew","family":"Smith","sequence":"first","affiliation":[{"name":"Queensland Fire and Emergency Services, Research and Scientific Branch Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mike","family":"Logan","sequence":"additional","affiliation":[{"name":"Queensland Fire and Emergency Services, Research and Scientific Branch Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikaela","family":"Bazley","sequence":"additional","affiliation":[{"name":"Chemistry Department University of Queensland St Lucia, Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne","family":"Blanchfield","sequence":"additional","affiliation":[{"name":"Chemistry Department University of Queensland St Lucia, Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Stokes","sequence":"additional","affiliation":[{"name":"Field Detection, Molecular Spectroscopy Agilent Technologies UK Ltd Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Blanco","sequence":"additional","affiliation":[{"name":"Field Detection, Molecular Spectroscopy Agilent Technologies UK Ltd Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"McGee","sequence":"additional","affiliation":[{"name":"Field Detection, Molecular Spectroscopy Agilent Technologies UK Ltd Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2017.12.031"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11419-017-0379-4"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.23907\/2017.004"},{"issue":"2","key":"e_1_2_6_5_1","first-page":"12","article-title":"Large fentanyl and MDA laboratory in Los Angeles, California","volume":"16","author":"Maroge W","year":"2006","journal-title":"J Clandest Lab Invest Chem Assoc"},{"key":"e_1_2_6_6_1","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1039\/9781782628071-00259","volume-title":"Chemical warfare toxicology. 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