{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T20:04:01Z","timestamp":1760385841489},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,2,9]],"date-time":"2021-02-09T00:00:00Z","timestamp":1612828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Forensic Sciences"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Mirtazapine is an antidepressant drug, used to treat depression, but also, in some specific conditions, to treat obsessive\u2013compulsive disorder and anxiety. Although mirtazapine is not a hypnotic, it can make the subject feel drowsy. Children\u00a0under the age of 18 should not take\u00a0mirtazapine, but for some very special diseases, a physician can prescribe it for a limited period of time. The authors report a case involving 2 children (7\u2010 and 9\u2010year\u2010old) who were administered mirtazapine without consent by the mother, who was under daily therapy with this antidepressant. Hair specimens, collected from the children were tested by liquid chromatography coupled to tandem mass spectrometry for mirtazapine and its metabolite, N\u2010desmethylmirtazapine, on 3\u00a0\u00d7\u00a01\u00a0cm segments. The hair test results (3\u00a0\u00d7\u00a01\u00a0cm segments) have demonstrated that both children have been repetitively exposed to mirtazapine for approximately the last 3\u00a0months before hair collection, with concentrations in the range 1.32\u20133.79 and 0.64\u20132.54\u00a0ng\/mg for mirtazapine and N\u2010desmethylmirtazapine, respectively. Environmental contamination was ruled out as the measured concentrations are highly variable according to the pattern of drug distribution and the washes were negative. Hair testing for drugs appears as an excellent diagnostic tool for child protection toward drug exposure.<\/jats:p>","DOI":"10.1111\/1556-4029.14684","type":"journal-article","created":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T20:41:28Z","timestamp":1612989688000},"page":"1165-1170","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Evidence of repeated mirtazapine poisoning in children by hair analysis"],"prefix":"10.1111","volume":"66","author":[{"given":"Pascal","family":"Kintz","sequence":"first","affiliation":[{"name":"Institut de M\u00e9decine L\u00e9gale Strasbourg France"},{"name":"X\u2010Pertise Consulting Mittelhausbergen France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010S\u00e9bastien","family":"Raul","sequence":"additional","affiliation":[{"name":"Institut de M\u00e9decine L\u00e9gale Strasbourg 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