{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T13:54:20Z","timestamp":1779371660250,"version":"3.53.1"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,9,29]],"date-time":"2021-09-29T00:00:00Z","timestamp":1632873600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Forensic Sciences"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The literature on pediatric sudden unexpected death (SUD) due to unrecognized mediastinal neoplasms is limited to a small number of case reports with several cases confirmed to be secondary to T\u2010cell lymphoblastic lymphoma (T\u2010cell LBL). Mediastinal T\u2010cell LBL can be rapidly progressive and potentially fatal due to the compression and obstruction of the airway and\/or the great vessels. The clinical presentation is nonspecific with a predominance of respiratory symptoms that are more apparent when the patient is supine. We presented three cases of pediatric SUD attributed to forensic autopsy\u2010diagnosed anterior mediastinal T\u2010 cell LBL. Case 1 involved a 2\u2010year\u2010old girl who presented with 9\u00a0days of cough and dyspnea. Postmortem examination revealed a firm rubbery mass surrounding the heart and compressing the bronchi. Case 2 involved a 3\u2010year\u2010old girl who suffered from a respiratory tract infection over several days. Autopsy revealed a firm nodular mass compressing the superior vena cava. Case 3 involved a 2\u2010year\u2010old boy who was found unresponsive, lying prone in his crib. He had cold\u2010like symptoms for several days before his death. Postmortem examination revealed a firm, rubbery anterior mediastinal neoplasm surrounding the superior vena cava and great arteries. These three cases demonstrate the importance of identifying children with mediastinal masses that could potentially lead to life\u2010threatening presentations and pediatric SUD. The forensic pathologist should consider a hematologic neoplasm at the time of autopsy in a previously healthy child who dies suddenly.<\/jats:p>","DOI":"10.1111\/1556-4029.14901","type":"journal-article","created":{"date-parts":[[2021,9,29]],"date-time":"2021-09-29T08:21:39Z","timestamp":1632903699000},"page":"795-801","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Pediatric sudden unexpected death due to undiagnosed mediastinal T\u2010cell lymphoblastic lymphoma: A series of three cases"],"prefix":"10.1111","volume":"67","author":[{"given":"Celeste","family":"Santos Martins","sequence":"first","affiliation":[{"name":"Cleveland Clinic Foundation  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Felo","sequence":"additional","affiliation":[{"name":"Cuyahoga County Medical Examiner\u2019s Office  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,29]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"NORD (National Organization for Rare Disorders).Sudden unexplained death in childhood. 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