{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T08:04:20Z","timestamp":1743408260489},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,9,29]],"date-time":"2021-09-29T00:00:00Z","timestamp":1632873600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Forensic Sciences"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Acute propofol intoxications appear rare and remain primarily related to the acquisition of the material from the hospital. In this study, two cases of suicide following self\u2010administration of a propofol\u2013atracurium combination are presented as well as other propofol\u2010related fatalities, in order to investigate propofol postmortem blood concentrations and circumstances surrounding death. The two case studies involved a 48\u2010years\u2010old male and a 61\u2010year\u2010old female, both anesthesiologists, who were found unresponsive with drugs (propofol, atracurium for both, and cisatracurium for one of them) discovered at the scene. Toxicological analyses were performed using validated chromatographic methods and highlighted the presence of propofol (1.0\u00a0\u00b5g\/ml), laudanosine (0.2\u00a0\u00b5g\/ml), paroxetine (3.4\u00a0\u00b5g\/ml), and ethanol (12\u00a0mg\/dl) for the first case and propofol (1.9\u00a0\u00b5g\/ml), laudanosine (1.2\u00a0\u00b5g\/ml), and hydroxyzine (0.03\u00a0\u00b5g\/ml) for the second case. In the literature, 14 publications describing 27 cases of propofol\u2010related lethal intoxications were identified. Except for two cases, all these fatalities involved healthcare professionals. Accidental overdose was the most frequently reported manner of death and the reported propofol blood concentrations ranged from 0.026 to 223.8\u00a0\u00b5g\/ml. These cases, in agreement with other reported cases, highlight the concerns related to the misuse of hospital\u2010based medicines, especially by health\u2010care professionals, and so, the need for a much more stringent internal control of such drugs.<\/jats:p>","DOI":"10.1111\/1556-4029.14903","type":"journal-article","created":{"date-parts":[[2021,9,29]],"date-time":"2021-09-29T21:47:18Z","timestamp":1632952038000},"page":"827-831","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Lethal self\u2010administration of propofol and atracurium"],"prefix":"10.1111","volume":"67","author":[{"given":"Guillaume","family":"Drevin","sequence":"first","affiliation":[{"name":"Service de Pharmacologie\u2010Toxicologie et Pharmacovigilance Centre Hospitalo\u2010Universitaire d\u2019Angers  Angers France"},{"name":"Universit\u00e9 d\u2019Angers  Angers France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie","family":"Briet","sequence":"additional","affiliation":[{"name":"Service de Pharmacologie\u2010Toxicologie et Pharmacovigilance Centre Hospitalo\u2010Universitaire d\u2019Angers  Angers France"},{"name":"Universit\u00e9 d\u2019Angers  Angers France"},{"name":"Laboratoire MitoVasc UMR CNRS 6215 INSERM 1083  Angers France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00e9verine","family":"Ferec","sequence":"additional","affiliation":[{"name":"Service de Pharmacologie\u2010Toxicologie et Pharmacovigilance Centre Hospitalo\u2010Universitaire d\u2019Angers  Angers France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lea\u2010Helena","family":"Rossi","sequence":"additional","affiliation":[{"name":"Institut de M\u00e9decine l\u00e9gale Centre Hospitalo\u2010Universitaire d\u2019Angers  Angers France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie","family":"Jousset","sequence":"additional","affiliation":[{"name":"Institut de M\u00e9decine l\u00e9gale Centre Hospitalo\u2010Universitaire d\u2019Angers  Angers France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chadi","family":"Abbara","sequence":"additional","affiliation":[{"name":"Service de Pharmacologie\u2010Toxicologie et Pharmacovigilance Centre Hospitalo\u2010Universitaire d\u2019Angers  Angers France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,9,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612043382846"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1016057229478"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/15563651003757954"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1472-8206.2007.00497.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0750-7658(85)80242-2"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsigen.2020.102433"},{"key":"e_1_2_8_8_1","unstructured":"U.S. Food and Drug Administration.Guidance for industry: bioanalytical method validation.2018.https:\/\/www.fda.gov\/files\/drugs\/published\/Bioanalytical\u2010Method\u2010Validation\u2010Guidance\u2010for\u2010Industry.pdf. 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