{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:26:54Z","timestamp":1747182414993,"version":"3.40.5"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,1,28]],"date-time":"2022-01-28T00:00:00Z","timestamp":1643328000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Forensic Sciences"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Forensic pathologists are required to investigate lethal trauma or disease at autopsy. In addition to massive contusions of various organs, a number of small features with potentially fatal implications also need to be sought. Since such lesions may need microscopic examinations for detailed evaluation, it is important to select suitable anatomic locations for tissue sampling. For practical screening of small lesions, we have developed a tissue optical clearing (TOC) technique for forensic autopsy. The technique involves clearing with a non\u2010toxic organic solvent, ethyl cinnamate, which renders excised organs transparent, while hemorrhages or blood\u2010containing vessels remain opaque. Using this technique, tiny hemorrhages in the spinal cord were able to be identified by gross examination, allowing proper selection of locations for tissue sampling. Subsequent histopathological evaluation was successfully performed with no apparent artifacts related with the TOC procedure. In addition, a combination of TOC and targeted CT angiography allowed feasible examination of the arterial occlusive lesion in the superior mesenteric artery, and when combined with micro\u2010CT scanning it was useful for evaluating the lumen of the coronary artery with stent implantation. The results obtained so far indicated that TOC could complement routine forensic autopsy procedures when detailed evaluation of small lesions is required.<\/jats:p>","DOI":"10.1111\/1556-4029.14995","type":"journal-article","created":{"date-parts":[[2022,1,28]],"date-time":"2022-01-28T12:23:25Z","timestamp":1643372605000},"page":"1124-1131","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Usefulness of a tissue optical clearing technique for forensic autopsy"],"prefix":"10.1111","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1156-2984","authenticated-orcid":false,"given":"Yoichiro","family":"Takahashi","sequence":"first","affiliation":[{"name":"Department of Legal Medicine Gunma University, Graduate School of Medicine  Maebashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Hayakawa","sequence":"additional","affiliation":[{"name":"Department of Legal Medicine Gunma University, Graduate School of Medicine  Maebashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rie","family":"Sano","sequence":"additional","affiliation":[{"name":"Department of Legal Medicine Gunma University, Graduate School of Medicine  Maebashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruki","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Department of Legal Medicine Gunma University, Graduate School of Medicine  Maebashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rieko","family":"Kubo","sequence":"additional","affiliation":[{"name":"Department of Legal Medicine Gunma University, Graduate School of Medicine  Maebashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Tokue","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology &amp; Nuclear Medicine, Graduate School of Medicine Gunma University  Maebashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takafumi","family":"Okawa","sequence":"additional","affiliation":[{"name":"Department of Legal Medicine Gunma University, Graduate School of Medicine  Maebashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miki","family":"Kawamura","sequence":"additional","affiliation":[{"name":"Department of Legal Medicine Gunma University, Graduate School of Medicine  Maebashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiko","family":"Kominato","sequence":"additional","affiliation":[{"name":"Department of Legal Medicine Gunma University, Graduate School of Medicine  Maebashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,1,28]]},"reference":[{"issue":"2","key":"e_1_2_8_2_1","first-page":"105","article-title":"The importance of the medico\u2010legal autopsy","volume":"19","author":"Nadesan K","year":"1997","journal-title":"Malays J Pathol."},{"issue":"12","key":"e_1_2_8_3_1","first-page":"703","article-title":"Medicolegal autopsy \u2013 What, why and how","volume":"100","author":"Yadwad BS","year":"2002","journal-title":"J Indian Med Assoc."},{"issue":"1","key":"e_1_2_8_4_1","first-page":"29","article-title":"Occlusion of the basilar artery. 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