{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T14:42:21Z","timestamp":1793371341606,"version":"4.5.0"},"reference-count":67,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,4,16]],"date-time":"2022-04-16T00:00:00Z","timestamp":1650067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["310057\/2020\u20105"],"award-info":[{"award-number":["310057\/2020\u20105"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["422555\/2018\u20105"],"award-info":[{"award-number":["422555\/2018\u20105"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Forensic Sciences"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The use of drugs of abuse has grown significantly in recent decades. In forensic chemistry, methods of identifying and characterizing illicit drugs contribute to the interests of researchers, experts, and public security authorities. Among existing methods, portable Raman spectroscopy is notable for performing rapid, non\u2010destructive, and highly selective analysis in the laboratory or on\u2010site. When the resulting spectral data are paired with chemometric tools, methods of exploratory analysis and multivariate calibration can be developed. Thus, this work describes the application of Raman spectroscopy associated with principal component analysis (PCA) and interval principal component analysis (iPCA) to assessing trends in samples of cocaine (<jats:italic>n<\/jats:italic>\u00a0=\u200940), crack (<jats:italic>n<\/jats:italic>\u00a0=\u200933), and their main adulterants (<jats:italic>n<\/jats:italic>\u00a0=\u20095) and diluents (<jats:italic>n<\/jats:italic>\u00a0=\u20095), tablets of ecstasy (<jats:italic>n<\/jats:italic>\u00a0=\u200914), designer drugs papers (<jats:italic>n<\/jats:italic>\u00a0=\u200927), and alcoholic solutions adulterated with benzodiazepines (alprazolam and diazepam). In addition, competitive adaptive reweighted sampling (CARS) combined with partial least squares (PLS) regression (CARSPLS) was used to quantify adulterants (benzocaine, lidocaine, and procaine) in binary mixtures with crack (<jats:italic>n<\/jats:italic>\u00a0=\u200921) and solutions of cacha\u00e7a adulterated with bromazepam (<jats:italic>n<\/jats:italic>\u00a0=\u200911).<\/jats:p>","DOI":"10.1111\/1556-4029.15011","type":"journal-article","created":{"date-parts":[[2022,4,17]],"date-time":"2022-04-17T04:44:06Z","timestamp":1650170646000},"page":"1399-1416","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Portable Raman spectroscopy applied to the study of drugs of abuse"],"prefix":"10.1111","volume":"67","author":[{"given":"Layla P.","family":"Santos","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Petrole\u00f4mica e Forense Universidade Federal do Esp\u00edrito Santo (UFES)  Vit\u00f3ria Brazil"},{"name":"Instituto Nacional de Ci\u00eancia e Tecnologia Forense (INCT Forense)  Vila Velha Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcia H. C.","family":"Nascimento","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Petrole\u00f4mica e Forense Universidade Federal do Esp\u00edrito Santo (UFES)  Vit\u00f3ria Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iago H. A. S.","family":"Barros","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Petrole\u00f4mica e Forense Universidade Federal do Esp\u00edrito Santo (UFES)  Vit\u00f3ria Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nayara A.","family":"Santos","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Petrole\u00f4mica e Forense Universidade Federal do Esp\u00edrito Santo (UFES)  Vit\u00f3ria Brazil"},{"name":"Instituto Nacional de Ci\u00eancia e Tecnologia Forense (INCT Forense)  Vila Velha Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Valdemar","family":"Lacerda","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Petrole\u00f4mica e Forense Universidade Federal do Esp\u00edrito Santo (UFES)  Vit\u00f3ria Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo R.","family":"Filgueiras","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Petrole\u00f4mica e Forense Universidade Federal do Esp\u00edrito Santo (UFES)  Vit\u00f3ria Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2254-6683","authenticated-orcid":false,"given":"Wanderson","family":"Rom\u00e3o","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Petrole\u00f4mica e Forense Universidade Federal do Esp\u00edrito Santo (UFES)  Vit\u00f3ria Brazil"},{"name":"Instituto Nacional de Ci\u00eancia e Tecnologia Forense (INCT Forense)  Vila Velha Brazil"},{"name":"Instituto Federal do Esp\u00edrito Santo (IFES)  Vila Velha Brazil"},{"name":"Academia Brasileira de Ci\u00eancias (ABC)  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,4,16]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"World drug report 2020 (United Nations publication Sales No. E.20.XI.6).[cited 2020 Aug 01]. Available from:https:\/\/www.unodc.org\/unodc\/en\/data\u2010and\u2010analysis\/wdr2021.html"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1590\/s0100\u201040422011001000005"},{"key":"e_1_2_8_4_1","unstructured":"DiasF.Amidst the pandemic and with closed borders drug seizures in MS rise by 101% in the last 2 months. May 13 2020. [cited 2020 Jul 5]. Available from:https:\/\/g1.globo.com\/ms\/mato\u2010grosso\u2010do\u2010sul\/noticia\/2020\/05\/13\/em\u2010meio\u2010a\u2010pandemia\u2010e\u2010com\u2010fronteiras\u2010fechadas\u2010apreensao\u2010de\u2010drogas\u2010em\u2010ms\u2010cresce\u2010101percent\u2010nos\u2010ultimos\u20102\u2010meses.ghtmladas\u2010apreensao\u2010de\u2010drogas\u2010em\u2010ms\u2010cresce\u2010101percent\u2010nos\u2010ultimos\u20102\u2010meses.ghtml"},{"key":"e_1_2_8_5_1","unstructured":"The amount of drugs used in ES in 2020 is five times higher than last year.2020 Dec 19. [cited 2020 Jul 5]. Available from:https:\/\/g1.globo.com\/es\/espirito\u2010santo\/noticia\/2020\/12\/19\/quantidade\u2010de\u2010droga\u2010apreendida\u2010no\u2010es\u2010em\u20102020\u2010e\u2010cinco\u2010vezes\u2010maior\u2010que\u2010no\u2010ano\u2010passado.ghtml"},{"key":"e_1_2_8_6_1","first-page":"135","volume-title":"Experimental forensic chemistry","author":"Martinis BS","year":"2015"},{"key":"e_1_2_8_7_1","first-page":"119","volume-title":"Forensic toxicology: theory and practice","author":"Passagli MF","year":"2018"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forc.2016.07.001"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.5935\/0100\u20104042.20140240"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1590\/s0100\u201040422010000300042"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forc.2017.11.002"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2018.09.038"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jms.4596"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11419\u2010017\u20100362\u20100"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0100\u201040422012001000025"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2004.11.011"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jrs.4826"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/dta.217"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejfs.2015.06.001"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jrs.4864"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1515\/psr\u20102017\u20100049"},{"issue":"6","key":"e_1_2_8_22_1","first-page":"26","article-title":"Recommendations for code of professional practice, education and training, methods of analysis, and quality assurance","volume":"1","author":"SWGDRUG","year":"2019","journal-title":"Sci Work Gr Anal Seized Drugs"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/05704928.2019.1576190"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0379\u20100738(01)00615\u20106"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/0003702818809719"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1117\/12.2017892"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/1556\u20104029.14217"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2020.110367"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/1556\u20104029.14563"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forc.2018.02.002"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1366\/000370203321165133"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/jrs.5496"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1080\/00450618.2017.1356867"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forc.2020.100241"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/jrs.6074"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.21577\/0103\u20105053.20190140"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2018.05.010"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0100\u201040422012000300030"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1039\/b922045c"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemolab.2015.10.003"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1366\/0003702001949500"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/cem.1248"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2009.06.046"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2015.06.056"},{"key":"e_1_2_8_45_1","volume-title":"Chemometric: Concepts, methods and applications","author":"Ferreira MMC","year":"2015"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003\u20102670(86)80028\u20109"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scijus.2015.11.006"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1080\/00387010.2019.1671871"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1080\/10739149.2012.686356"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/1556\u20104029.12666"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/jrs.5231"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cplett.2019.06.067"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2016.03.077"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics6040651"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vibspec.2016.09.015"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1366\/11\u201006310"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2016.01.024"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/bkx004"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.4626"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/dta.1518"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1039\/b405290k"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.5b02899"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/jrs.2352"},{"issue":"13","key":"e_1_2_8_64_1","first-page":"95","article-title":"Fourier transform infrared and laser Raman spectroscopic investigations on 2\u2010N\u2010(benzoylamino) pyridine","volume":"101","author":"Gunasekaran S","year":"1993","journal-title":"J Phys"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/1556\u20104029.12584"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1039\/c8an01829d"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/dta.1969"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.2116\/analsci.19P361"}],"container-title":["Journal of Forensic Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1556-4029.15011","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1556-4029.15011","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1556-4029.15011","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T17:19:20Z","timestamp":1692811160000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1556-4029.15011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,16]]},"references-count":67,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["10.1111\/1556-4029.15011"],"URL":"https:\/\/doi.org\/10.1111\/1556-4029.15011","archive":["Portico"],"relation":{},"ISSN":["0022-1198","1556-4029"],"issn-type":[{"value":"0022-1198","type":"print"},{"value":"1556-4029","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,16]]},"assertion":[{"value":"2021-09-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}