{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T13:22:46Z","timestamp":1787750566147,"version":"build-2784847793"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T00:00:00Z","timestamp":1666742400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005632","name":"Narodowe Centrum Bada\u0144 i Rozwoju","doi-asserted-by":"publisher","award":["POIR.01.01.01\u201000\u20100175\/18"],"award-info":[{"award-number":["POIR.01.01.01\u201000\u20100175\/18"]}],"id":[{"id":"10.13039\/501100005632","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Forensic Sciences"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Synthetic cathinones comprise a large amount of substances present on the dark market, which creates an undeniably worldwide problem and still is posing a threat. A 22\u2010year\u2010old man was brought to the Emergency Room from a party, where he had ingested orally 20\u2009g of mephedrone. The man exhibited a disorder of consciousness with no logical verbal contact and dilated pupils. Moreover, a metabolic acidosis was present. The patient died after an hour from an admission to the ER. Blood and vitreous humor collected during an autopsy were analyzed with the use of an ultra\u2010high\u2010performance liquid chromatography\u2010tandem mass spectrometry (UHPLC\u2010QqQ\u2010MS\/MS) with the use of C18 column in multiple reaction monitoring (MRM) mode. Both biological specimens were prepared using liquid\u2013liquid extraction (LLE) with the use of ethyl acetate and 0.5\u00a0M ammonium carbonate water solution (pH\u00a09). The limit of quantification (LOQ) of the method was 0.5\u00a0ng\/ml in both matrices; precision and accuracy values did not exceed \u00b115%. Recovery of the method was in the range of 86.1%\u2013102.7%. Determined concentrations of 4\u2010CMC were 8542 and 9874\u2009ng\/ml in blood and vitreous humor, respectively. Other substances present in both biological materials were: atropine, diazepam, lidocaine, and its metabolite norlidocaine, as well as methcathinone and ethyl alcohol. The concentration presented in here described case is the highest ever reported 4\u2010CMC concentration. Important aspect is also receiving other NPS by recreational users than intended, which lead to accidental poisoning (in presented case user assumed 4\u2010CMC was 4\u2010MMC).<\/jats:p>","DOI":"10.1111\/1556-4029.15162","type":"journal-article","created":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T11:50:12Z","timestamp":1666785012000},"page":"349-354","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["A fatal case involving the highest ever reported 4\u2010<scp>CMC<\/scp> concentration"],"prefix":"10.1111","volume":"68","author":[{"given":"Kaja","family":"Tusiewicz","sequence":"first","affiliation":[{"name":"Department of Forensic Medicine Wroclaw Medical University  Wroclaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Ch\u0142opa\u015b\u2010Konowa\u0142ek","sequence":"additional","affiliation":[{"name":"Institute of Toxicology Research  Borowa Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Wache\u0142ko","sequence":"additional","affiliation":[{"name":"Institute of Toxicology Research  Borowa Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcin","family":"Zawadzki","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine Wroclaw Medical University  Wroclaw Poland"},{"name":"Institute of Toxicology Research  Borowa Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawe\u0142","family":"Szpot","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine Wroclaw Medical University  Wroclaw Poland"},{"name":"Institute of Toxicology Research  Borowa Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,26]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"European Monitoring Centre for Drugs and Drug Addiction.European drug report 2021: Trends and developments. Publications Office of the European Union;2021. Luxembourg.https:\/\/www.emcdda.europa.eu\/system\/files\/publications\/13838\/TDAT21001ENN.pdf. Accessed 30 Aug 2022."},{"key":"e_1_2_8_3_1","unstructured":"European Monitoring Centre for Drugs and Drug Addiction.European drug report 2020: Trends and developments. Publications Office of the European Union;2020. Luxembourg.https:\/\/www.emcdda.europa.eu\/system\/files\/publications\/13236\/TDAT20001ENN_web.pdf. 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