{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:41:45Z","timestamp":1787013705525,"version":"build-2736575974"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,2,13]],"date-time":"2023-02-13T00:00:00Z","timestamp":1676246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Forensic Sciences"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>With the emergence of new psychoactive substances (NPSs) over the years, the substances detected on stamps (also known as blotter papers) have also evolved from the traditional drug\u2014lysergic acid diethylamide (LSD) to the multiple variants of lysergamides such as ALD\u201052 and 1P\u2010LSD. The analysis of such blotter papers is usually done by solvent extraction followed by identification using gas chromatography\u2013mass spectrometry (GC\u2010MS). This study has shown that hydrolysis to form LSD was observed in GC\u2010MS analysis when ALD\u201052 was extracted with methanol. The extraction of ALD\u201052 using other solvents such as acetonitrile, ethanol, isopropyl alcohol, ethyl acetate, and acetone, followed by GC\u2010MS analysis, was investigated. It is shown that alcoholic solvents such as methanol and ethanol will result in the conversion of ALD\u201052 to LSD during GC\u2010MS analysis, whereas the sterically hindered isopropyl alcohol will prevent this conversion. Investigation also shows that the hydrolysis of ALD\u201052 to LSD occurs at the GC injector port. It was also observed that the degree of hydrolysis was more pronounced at a lower concentration (0.1\u00a0mg\/mL). The study was extended to a close analog\u20141P\u2010LSD, and the results showed that 1P\u2010LSD similarly hydrolyzes to LSD. However, 1P\u2010LSD was observed to be more stable than ALD\u201052 due to steric hindrance because of the propanoyl group.<\/jats:p>","DOI":"10.1111\/1556-4029.15224","type":"journal-article","created":{"date-parts":[[2023,2,13]],"date-time":"2023-02-13T06:30:31Z","timestamp":1676269831000},"page":"1009-1019","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Stability studies of\n                    <scp>ALD<\/scp>\n                    \u201052 and its homologue\n                    <scp>1P\u2010LSD<\/scp>"],"prefix":"10.1111","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0116-0252","authenticated-orcid":false,"given":"Shu\u2010Hua","family":"Zhang","sequence":"first","affiliation":[{"name":"Illicit Drugs Laboratory, Illicit Drugs Division, Applied Sciences Group Health Sciences Authority  Singapore City Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angeline S. Y.","family":"Tang","sequence":"additional","affiliation":[{"name":"Illicit Drugs Laboratory, Illicit Drugs Division, Applied Sciences Group Health Sciences Authority  Singapore City Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reenie S. L.","family":"Chin","sequence":"additional","affiliation":[{"name":"Illicit Drugs Laboratory, Illicit Drugs Division, Applied Sciences Group Health Sciences Authority  Singapore City Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia Ying","family":"Goh","sequence":"additional","affiliation":[{"name":"Illicit Drugs Laboratory, Illicit Drugs Division, Applied Sciences Group Health Sciences Authority  Singapore City Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei Ching","family":"Ong","sequence":"additional","affiliation":[{"name":"Illicit Drugs Laboratory, Illicit Drugs Division, Applied Sciences Group Health Sciences Authority  Singapore City Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy J. L.","family":"Lim","sequence":"additional","affiliation":[{"name":"Illicit Drugs Laboratory, Illicit Drugs Division, Applied Sciences Group Health Sciences Authority  Singapore City Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angeline T. W.","family":"Yap","sequence":"additional","affiliation":[{"name":"Illicit Drugs Laboratory, Illicit Drugs Division, Applied Sciences Group Health Sciences Authority  Singapore City Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheuk\u2010Wai","family":"So","sequence":"additional","affiliation":[{"name":"School of Chemistry, Chemical Engineering and Biotechnology Nanyang Technological University  Singapore City Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,2,13]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"The convention on psychotropic substances of 1971. United Nations1971.https:\/\/www.unodc.org\/pdf\/convention_1971_en.pdf. Accessed 21 Sep 2022."},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11419\u2010017\u20100357\u2010x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11419\u2010019\u201000496\u20109"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1039\/c9an00062c"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2019.05.036"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2019.109969"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forc.2019.100164"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/chromsci\/bmw095"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hlca.19570400619"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/dta.1884"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/dta.1985"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/dta.2196"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/dta.2222"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/dta.2613"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/dta.2789"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/jaoac\/51.1.164"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042\u20107158.1969.tb08160.x"},{"key":"e_1_2_8_19_1","unstructured":"European project: Response to challenges in forensic drugs analyses. Analytical report on ALD\u201052.https:\/\/www.policija.si\/apps\/nfl_response_web\/0_Analytical_Reports_final\/ALD\u201052\u2010ID\u20101404\u201016_report.pdf. Accessed 10 Oct 2022."},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11419\u2010017\u20100362\u20100"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2017.06.002"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11419\u2010013\u20100221\u20106"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/app.23280"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/hup.2599"},{"key":"e_1_2_8_25_1","first-page":"117","volume-title":"TIHKAL: the continuation","author":"Shulgin A","year":"1997"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1984\u201082502010000400011"},{"key":"e_1_2_8_27_1","first-page":"843","volume-title":"Organic chemistry","author":"McMurry JE","year":"2012"}],"container-title":["Journal of Forensic Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1556-4029.15224","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1556-4029.15224","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1556-4029.15224","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,25]],"date-time":"2023-12-25T04:47:38Z","timestamp":1703479658000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1556-4029.15224"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,13]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["10.1111\/1556-4029.15224"],"URL":"https:\/\/doi.org\/10.1111\/1556-4029.15224","archive":["Portico"],"relation":{},"ISSN":["0022-1198","1556-4029"],"issn-type":[{"value":"0022-1198","type":"print"},{"value":"1556-4029","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,13]]},"assertion":[{"value":"2022-11-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}