{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T00:25:37Z","timestamp":1793060737154,"version":"4.5.0"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,3,26]],"date-time":"2023-03-26T00:00:00Z","timestamp":1679788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Forensic Sciences"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Public health, public safety, and forensic science personnel continue to face the emergence of new compounds into the drug market. While focus is often put on the detection of new analogs of known illicit drugs, monitoring the changes in cutting agents and other compounds can be equally as important. Over the last year, near real\u2010time monitoring of the drug supply in Maryland has been completed through a public health\u2013public safety partnership whereby residue from suspected drug packaging or used paraphernalia is collected and analyzed. Through this project, we have recently detected the presence of the veterinary sedative medetomidine in a small number of samples. The presence of medetomidine has been identified in both public health and law enforcement samples and in the presence of fentanyl and xylazine\u2014another veterinary sedative that has been widely observed over the last year. While the rate at which medetomidine has been detected remains low, it is concerning and worthy of continued monitoring.<\/jats:p>","DOI":"10.1111\/1556-4029.15242","type":"journal-article","created":{"date-parts":[[2023,3,26]],"date-time":"2023-03-26T08:23:30Z","timestamp":1679819010000},"page":"1708-1712","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Identification of the veterinary sedative medetomidine in combination with opioids and xylazine in Maryland"],"prefix":"10.1111","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0252-1910","authenticated-orcid":false,"given":"Edward","family":"Sisco","sequence":"first","affiliation":[{"name":"National Institute of Standards and Technology  Gaithersburg Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9840-6903","authenticated-orcid":false,"given":"Meghan","family":"Appley","sequence":"additional","affiliation":[{"name":"National Institute of Standards and Technology  Gaithersburg Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,26]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"NPS discovery: year in review 2022","author":"Krotulski AJ","year":"2022"},{"key":"e_1_2_9_3_1","volume-title":"Early warning system \u2014 national profiles","author":"Gallegos A","year":"2012"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1556\u20104029.2007.00648.x"},{"key":"e_1_2_9_5_1","volume-title":"The growing threat of xylazine and its mixture with illicit drugs","year":"2022"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAF.0000000000000622"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2021.07.010"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2022.109380"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm7113a3"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmrw.mm7037a4"},{"issue":"7","key":"e_1_2_9_11_1","first-page":"458","article-title":"Acepromazine revisited","volume":"35","author":"Brock N","year":"1994","journal-title":"Can Vet J"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042\u20103306.1986tb03655.x"},{"key":"e_1_2_9_13_1","first-page":"85","article-title":"Introduction to the clinical pharmacology of medetomidine","volume":"85","author":"Vainio O","year":"1989","journal-title":"Acta Vet Scand Suppl"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467\u20102995.2008.00412.x"},{"issue":"3","key":"e_1_2_9_15_1","first-page":"259","article-title":"The use of medetomidine, medetomidine\u2010ketamine combinations, and atipamezole in nondomestic mammals: a review","volume":"21","author":"Jalanka HH","year":"1990","journal-title":"J Zoo Wildl Med"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2000.216.1578"},{"key":"e_1_2_9_17_1","first-page":"341","volume-title":"Veterinary pharmacology and therapeutics","author":"Riviere JE","year":"2009"},{"issue":"11","key":"e_1_2_9_18_1","first-page":"885","article-title":"A review of the physiological effects of \u03b12\u2010agonists related to the clinical use of medetomidine in small animal practice","volume":"44","author":"Sinclair MD","year":"2003","journal-title":"Can Vet J"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.26434\/chemrxiv\u20102022\u2010bd64n"},{"key":"e_1_2_9_20_1","unstructured":"NIST DART\u2010MS Forensics Database (Is\u2010CID).https:\/\/data.nist.gov\/od\/id\/mds2\u20102313. 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