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A method using ultra\u2010high\u2010performance liquid chromatography\u2013tandem mass spectrometry system was applied in two fatal cases of colchicine poisoning in this study to the determination of colchicine in blood. In case 1, a 19\u2010year\u2010old man suffered from depression and ingested 160 colchicine tablets (each 0.5\u2009mg). The concentration of colchicine in his blood samples showed a fluctuating trend and kept above the therapeutic steady\u2010state concentration for 5\u2009days. In case 2, a 70\u2010year\u2010old female patient with a history of gout and chronic colchicine intake ingested five times the usual dose of colchicine (5\u2009mg) and died after 12\u2009days of medical care, with 5\u2009ng\/mL of colchicine in her blood sample. Our findings suggest that the delayed elimination and accumulation in humans after colchicine overdose could keep the concentration of colchicine maintaining above the therapeutic steady\u2010state concentration for many days before dying, probably along with a fluctuating trend.<\/jats:p>","DOI":"10.1111\/1556-4029.15298","type":"journal-article","created":{"date-parts":[[2023,5,31]],"date-time":"2023-05-31T05:52:07Z","timestamp":1685512327000},"page":"1425-1430","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Delayed elimination in humans after ingestion of colchicine: Two fatal cases of colchicine poisoning"],"prefix":"10.1111","volume":"68","author":[{"given":"Hongxiao","family":"Deng","sequence":"first","affiliation":[{"name":"Shanghai Key Laboratory of Forensic Medicine, Department of Forensic Toxicology Academy of Forensic Science  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Xiang","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Forensic Medicine, Department of Forensic Toxicology Academy of Forensic Science  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Forensic Medicine, Department of Forensic Toxicology Academy of Forensic Science  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hejian","family":"Wu","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Forensic Medicine, Department of Forensic Toxicology Academy of Forensic Science  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Forensic Medicine, Department of Forensic Toxicology Academy of Forensic Science  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Yan","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Forensic Medicine, Department of Forensic Toxicology Academy of Forensic Science  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,30]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"506","volume-title":"Disposition of toxic drugs and chemicals in man","author":"Randall CB","year":"2020"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/1658\u2010354X.136629"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2004.02.040"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007691\u2010200412000\u201000017"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.4103\/abr.abr_129_20"},{"key":"e_1_2_9_7_1","unstructured":"DoranE.CNY boss poisoning: death by colchicine overdose \u201ca terrible way to go \u201d expert says. 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