{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T04:38:14Z","timestamp":1781584694909,"version":"3.54.5"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T00:00:00Z","timestamp":1686096000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Forensic Sciences"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Acetone presence in human biological specimens can result from exogenous administration or endogenous production, resulting from diabetes, dietary composition, alcoholism, and stress response. Victims of drug\u2010facilitated sexual assaults (DFSA) are understood to experience enhanced stress. At the Harris County Institute of Forensic Sciences (HCIFS), DFSA drug testing includes analysis of volatile compounds, ethanol, methanol, isopropanol, and acetone, by headspace gas chromatography\/flame ionization detection. The prevalence of acetone\u2010positive specimens in DFSA casework has been observed to exceed that of other human performance case types. In this report, DFSA cases received between 2019 and 2021 (<jats:italic>n<\/jats:italic>\u2009=\u2009393) were reviewed and 41 acetone\u2010positive cases were detailed. Overall, nearly 11% of the DFSA cases had acetone\u2010positive blood or urine specimens, where 3% identified acetone only, 6% identified acetone and other drug(s), and 2% identified acetone, ethanol, and other drug(s). Acetone concentrations ranged from 0.010 to 0.147\u2009g\/100\u2009mL in urine. Other drugs such as nor\u2010carboxy\u2010\u0394<jats:sup>9<\/jats:sup>\u2010tetrahydrocannabinol, amphetamine, methamphetamine, ethanol, and benzoylecgonine were commonly detected. Elevated stress response encountered during DFSAs may facilitate the mechanism behind enhanced acetone production leading to increased identification. Limited availability of victim medical history precludes understanding the contribution of other disease states or physiological conditions. Nonetheless, the identification of acetone in DFSA specimens supports its potential as a biomarker of trauma in forensic toxicology casework and warrants future research within the community.<\/jats:p>","DOI":"10.1111\/1556-4029.15308","type":"journal-article","created":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T16:27:32Z","timestamp":1686155252000},"page":"1431-1435","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Examination of acetone findings in suspected drug\u2010facilitated sexual assaults: A case series"],"prefix":"10.1111","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3980-233X","authenticated-orcid":false,"given":"Crystal","family":"Arndt","sequence":"first","affiliation":[{"name":"Harris County Institute of Forensic Sciences  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5343-0335","authenticated-orcid":false,"given":"Kaitlyn B.","family":"Palmquist","sequence":"additional","affiliation":[{"name":"Harris County Institute of Forensic Sciences  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa R.","family":"Gray","sequence":"additional","affiliation":[{"name":"Harris County Institute of Forensic Sciences  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,7]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"15","volume-title":"Disposition of toxic drugs and chemicals in man","author":"Baselt RC","year":"2020"},{"issue":"5","key":"e_1_2_8_3_1","first-page":"429","article-title":"Disposition of acetone following acute acetone intoxication","volume":"129","author":"Ramu A","year":"1978","journal-title":"West J Med"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.18466"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134\u2010002\u20101575\u20100"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1017\/s0265021507000245"},{"key":"e_1_2_8_7_1","first-page":"10","volume-title":"Toxicological profile for acetone","author":"Agency for Toxic Substances and Disease Registry","year":"2022"},{"key":"e_1_2_8_8_1","first-page":"658","volume-title":"Clinical methods: the history, physical, and laboratory examinations","author":"Comstock JP","year":"1990"},{"key":"e_1_2_8_9_1","volume-title":"StatPearls [Internet]","author":"Dhillon KK","year":"2022"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr060412s"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2014.03.008"},{"key":"e_1_2_8_12_1","unstructured":"Texas Health and Human Services.Information for survivors of sexual assault.https:\/\/www.hhs.texas.gov\/providers\/health\u2010care\u2010facilities\u2010regulation\/information\u2010survivors\u2010sexual\u2010assault. Accessed 13 Mar 2023"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/00085030.1986.10757401"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/bkz110"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.30.6.510"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.31.3.242"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12872\u2010017\u20100713\u20100"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2014.01.006"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nutx.2019.100005"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0196\u20100644(96)70274\u20103"},{"key":"e_1_2_8_21_1","volume-title":"Standards board. Standard for the analytical scope and sensitivity of forensic toxicological testing of urine in drug\u2010facilitated crime investigations. ANSI\/ASB standard 121","author":"AAFS","year":"2021"}],"container-title":["Journal of Forensic Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1556-4029.15308","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,5]],"date-time":"2025-04-05T21:18:46Z","timestamp":1743887926000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1556-4029.15308"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,7]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["10.1111\/1556-4029.15308"],"URL":"https:\/\/doi.org\/10.1111\/1556-4029.15308","archive":["Portico"],"relation":{},"ISSN":["0022-1198","1556-4029"],"issn-type":[{"value":"0022-1198","type":"print"},{"value":"1556-4029","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,7]]},"assertion":[{"value":"2023-05-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}