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This study analyzes homicide data from the National Violent Death Reporting System (NVDRS) covering 49 US states, the District of Columbia, and Puerto Rico from 2012 to 2020. Case inclusion criteria included: (1) manner of death of homicide, and (2) sex work\u2010related circumstance. Descriptive analyses examined victim and injury characteristics, suspect information, and circumstances. The study identified 321 sex work\u2010related homicides (54% female, 41% male, 6% transgender). Among female victims, 94% were sex workers, and 54% of their suspects were clients. Money conflicts (23%) and other crimes (30%), most often in progress, commonly precipitated homicides of female victims. Substance use problems were reported in 49% of female victims, with 25% of their suspected perpetrators reportedly using substances in the preceding hours. For male victims, 54% were clients and 9% were sex workers. Suspects in male homicides were primarily sex workers (34%) or individuals engaged in sex work\u2010adjacent criminal activities (36%). Money conflicts (49%), other crimes (47%) most often in progress, and sex trafficking involvement (25%) commonly precipitated homicides with male victims. Transgender sex worker victims were mostly transfeminine (94%) and non\u2010Hispanic black (89%). Money conflicts (78%) most commonly precipitated homicides among transgender sex worker victims. These findings can inform prevention strategies addressing underlying risk factors for persons involved in sex work.<\/jats:p>","DOI":"10.1111\/1556-4029.15434","type":"journal-article","created":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T18:17:53Z","timestamp":1700677073000},"page":"529-541","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Sex work\u2010related homicides: Insights from the National Violent Death Reporting System, 2012\u20132020"],"prefix":"10.1111","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1313-6471","authenticated-orcid":false,"given":"Brenda L.","family":"Nguyen","sequence":"first","affiliation":[{"name":"Division of Violence Prevention Centers for Disease Control and Prevention  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine A.","family":"Fowler","sequence":"additional","affiliation":[{"name":"Division of Violence Prevention Centers for Disease Control and Prevention  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carter J.","family":"Betz","sequence":"additional","affiliation":[{"name":"Division of Violence Prevention Centers for Disease Control and Prevention  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8724-0562","authenticated-orcid":false,"given":"Kara","family":"Tsukerman","sequence":"additional","affiliation":[{"name":"Division of Violence Prevention, Centers for Disease Control and Prevention Oak Ridge Institute for Science and Education, ORISE Fellow  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon G.","family":"Smith","sequence":"additional","affiliation":[{"name":"Division of Violence Prevention Centers for Disease Control and Prevention  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2022.101658"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwh110"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/bsl.2528"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1556\u20104029.2006.00206.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/00918369.2019.1656029"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/0886260507312946"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/08862605211064289"},{"key":"e_1_2_9_9_1","unstructured":"United States department of justice.Human Trafficking.www.justice.gov\/humantrafficking. 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