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Understanding the synthetic processes of ketamine can provide essential clues for law enforcement officers against illicit ketamine manufacturing. In this case report, a chemical company was being monitored by law enforcement officers due to its importation of precursors and materials that could be used for the synthesis of illicit drugs. After materials and products seized from this chemical company were employed for analyses using gas chromatography\u2013mass spectrometry, liquid chromatography\u2013high\u2010resolution mass spectrometry, and nuclear magnetic resonance analyses, ketamine, hydroxylamine, 2\u2010chlorophenyl cyclopentyl ketone, and cyclopentanone p\u2010toluenesulfonylhydrazone were identified. In addition, a novel process for the synthesis of ketamine precursor 2\u2010chlorophenyl cyclopentyl ketone from cyclopentanone p\u2010toluenesulfonylhydrazone and 2\u2010chlorobenzaldehyde was validated. This is the first report to uncover this novel process for the synthesis of 2\u2010chlorophenyl cyclopentyl ketone and can be used to increase awareness among law enforcement officers and forensic practitioners about these novel starting materials for the synthesis of ketamine.<\/jats:p>","DOI":"10.1111\/1556-4029.15440","type":"journal-article","created":{"date-parts":[[2023,12,14]],"date-time":"2023-12-14T07:44:39Z","timestamp":1702539879000},"page":"688-697","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["New materials used for the synthesis of 2\u2010chlorophenyl cyclopentyl ketone seized from an illicit ketamine manufacturing unit"],"prefix":"10.1111","volume":"69","author":[{"given":"Yao\u2010Te","family":"Yen","sequence":"first","affiliation":[{"name":"Department of Forensic Science Investigation Bureau, Ministry of Justice  New Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hung\u2010Fan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Forensic Science Investigation Bureau, Ministry of Justice  New Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung\u2010Feng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Forensic Science Investigation Bureau, Ministry of Justice  New Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Ti","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Forensic Science Investigation Bureau, Ministry of Justice  New Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"San\u2010Chong","family":"Chyueh","sequence":"additional","affiliation":[{"name":"Department of Forensic Science Investigation Bureau, Ministry of Justice  New Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/da.22536"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.12063"},{"key":"e_1_2_9_4_1","unstructured":"United Nations Office on Drugs and Crime.Synthetic drugs in east and southeast Asia: Latest developments and challenges.2022.https:\/\/www.unodc.org\/documents\/scientific\/Synthetic_Drugs_in_East_and_Southeast_Asia_2022_web.pdf. 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