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Adulterants are often added to the mix, and the primary substance may be secretly replaced by a new one. Once\u2010known tablets can now be vastly different from what they are sold as, all due to the pursuit of profit and evasion of current drug regulations. These alterations in drug composition pose a threat to society, as their effects are still not well understood. Therefore, it is crucial for police intelligence and public health development to obtain the chemical profiles of illicit drugs. This study presents the chemical fingerprinting of ecstasy tablets seized in the state of Rio de Janeiro (Brazil) between 2012 and 2021. The tablet samples were weighed, extracted, diluted with methanol, and acidified before analysis using gas chromatography high\u2010resolution mass spectrometry and attenuated total reflection Fourier transform infrared spectroscopy. The major constituents found were MDMA and clobenzorex, with fewer occurrences of MDA, MDEA, and 2C\u2010B. 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These findings can help police intelligence units anticipate the behavior of the illicit market during major events, identify traffic routes, and support public health initiatives.<\/jats:p>","DOI":"10.1111\/1556-4029.15536","type":"journal-article","created":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T10:51:01Z","timestamp":1714560661000},"page":"1198-1211","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Qualitative transformations of street\u2010seized ecstasy over a decade: A case study in Rio de Janeiro (Brazil)"],"prefix":"10.1111","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3247-5740","authenticated-orcid":false,"given":"Ananda da Silva","family":"Antonio","sequence":"first","affiliation":[{"name":"Instituto de Qu\u00edmica, N\u00facleo de An\u00e1lises Forenses (NAF) \u2013 Laborat\u00f3rio de Apoio Ao Desenvolvimento Tecnol\u00f3gico (LADETEC) Universidade Federal do Rio de Janeiro  Rio de Janeiro RJ Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6706-7547","authenticated-orcid":false,"given":"Gleicielle Tozzi","family":"Wurzler","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica, N\u00facleo de An\u00e1lises Forenses (NAF) \u2013 Laborat\u00f3rio de Apoio Ao Desenvolvimento Tecnol\u00f3gico (LADETEC) Universidade Federal do Rio de Janeiro  Rio de Janeiro RJ Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cec\u00edlia de Andrade","family":"Bhering","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica, N\u00facleo de An\u00e1lises Forenses (NAF) \u2013 Laborat\u00f3rio de Apoio Ao Desenvolvimento Tecnol\u00f3gico (LADETEC) Universidade Federal do Rio de Janeiro  Rio de Janeiro RJ Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana Sousa","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Secretaria de Estado de Pol\u00edcia Civil (SEPOL) Instituto de Criminal\u00edstica Carlos \u00c9boli (ICCE)  Rio de Janeiro RJ Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana Silva do Amaral","family":"Cohen","sequence":"additional","affiliation":[{"name":"Secretaria de Estado de Pol\u00edcia Civil (SEPOL) Instituto de Criminal\u00edstica Carlos \u00c9boli (ICCE)  Rio de Janeiro RJ Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco Ant\u00f4nio Martins","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Secretaria de Estado de Pol\u00edcia Civil (SEPOL) Instituto de Criminal\u00edstica Carlos \u00c9boli (ICCE)  Rio de Janeiro RJ Brazil"},{"name":"Instituto de Qu\u00edmica, GQA Universidade Federal Fluminense  Niter\u00f3i RJ Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Radler","family":"de Aquino\u00a0Neto","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica, N\u00facleo de An\u00e1lises Forenses (NAF) \u2013 Laborat\u00f3rio de Apoio Ao Desenvolvimento Tecnol\u00f3gico (LADETEC) Universidade Federal do Rio de Janeiro  Rio de Janeiro RJ Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Vanini","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica, N\u00facleo de An\u00e1lises Forenses (NAF) \u2013 Laborat\u00f3rio de Apoio Ao Desenvolvimento Tecnol\u00f3gico (LADETEC) Universidade Federal do Rio de Janeiro  Rio de Janeiro RJ Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,1]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.4172\/2325\u20109841.1000111"},{"key":"e_1_2_8_3_1","unstructured":"United Nations Office on Drugs and Crime (UNODC).Global overview: Drug demand drug supply. 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