{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T02:57:24Z","timestamp":1788922644432,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T00:00:00Z","timestamp":1725408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82072110"],"award-info":[{"award-number":["82072110"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010881","name":"Suzhou Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["SKJY2021046"],"award-info":[{"award-number":["SKJY2021046"]}],"id":[{"id":"10.13039\/501100010881","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Forensic Sciences"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Diester diterpenoid alkaloids (DDAs) are the main active ingredients of herbaceous perennial plants <jats:italic>Aconitum<\/jats:italic>. DDAs possess cardiotoxic and neurotoxic properties. Although most deaths caused by DDA poisoning are accidental, a few instances of suicide and homicide have been reported. Presented is a case of an acute aconitine (AC) poisoning following the ingestion of approximately 50\u2009mL of homemade medicinal liquor. We described the clinical manifestations after poisoning and detailed postmortem changes, and detected the concentrations of AC and hypaconitine (HA) by liquid chromatography\u2013tandem mass spectrometry (LC\u2013MS\/MS). The decedent experienced a burning sensation in the gastrointestinal tract after poisoning, followed by flushing and paralysis of the face and limbs, and severe cardiac arrhythmia. An autopsy revealed cyanosis of the lips and nail beds; conjunctival hemorrhage in both eyes; pulmonary edema; tissue hemorrhage and congestion in multiple organs; and inflammatory cell infiltration in the stomach, duodenum, pancreas, and cardiac muscle. The concentrations of AC and HA were as follows: cardiac blood, 38.4\u2009ng\/mL and 7.1\u2009ng\/mL; pericardial fluid, 7.3\u2009ng\/mL and 41\u2009ng\/mL; urine, 28.1\u2009ng\/mL and 574\u2009ng\/mL; bile, 38.5\u2009ng\/mL and 108\u2009ng\/mL; gastric contents, 0.06\u2009mg and 0.56\u2009mg; liver tissue, 10.7\u2009ng\/g and 109.6\u2009ng\/g; and medicinal liquor, 0.568\u2009mg\/mL and 0.664\u2009mg\/mL, respectively. The clinical manifestations, anatomy findings, and quantitative data on the concentrations of AC and HA in body fluids and tissues will aid forensic investigations of deaths caused by acute AC poisoning.<\/jats:p>","DOI":"10.1111\/1556-4029.15621","type":"journal-article","created":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T04:29:52Z","timestamp":1725510592000},"page":"2317-2324","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Acute aconitine poisoning resulting from the ingestion of medicinal liquor"],"prefix":"10.1111","volume":"69","author":[{"given":"Ruoyu","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Forensic Medicine and Judicial Appraisal Center School of Basic Medicine and Biological Sciences, Suzhou Medicine College of Soochow University  Suzhou 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