{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T04:56:51Z","timestamp":1776056211705,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T00:00:00Z","timestamp":1763078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T00:00:00Z","timestamp":1763078400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Forensic Sciences"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Sexual dysfunction is a health issue that significantly affects adults. However, the increased demand for pharmacological treatments, such as sildenafil, tadalafil, and vardenafil has led to the emergence of counterfeit drugs, posing a serious public health concern. These counterfeit drugs and their analogs often lack clinical validation, leaving their effects on the human body largely unknown. In this case study, a suspected novel vardenafil analogue adulterated in sexual enhancement capsules was identified using gas chromatography\u2013mass spectrometry (GC\u2013MS). High\u2010resolution mass spectrometry (LC\u2010HRMS) was employed to determine the protonated molecular ion at\n                    <jats:italic>m<\/jats:italic>\n                    \/\n                    <jats:italic>z<\/jats:italic>\n                    562.2438 for the compound, and its possible elemental compositions were predicted. Based on AI\u2010assisted analysis using ChatGPT\u20134o, the compound was inferred to be KD\u2010027 (SLx\u20102101), a potential phosphodiesterase type 5 (PDE5) inhibitor. Following purification by column chromatography, nuclear magnetic resonance (NMR) spectroscopy confirmed this structure. In addition, evidence of coexisting E\/Z tautomerism of KD\u2010027 was observed in the NMR data. To the best of our knowledge, this is the first report to identify KD\u2010027 in sexual enhancement products, providing its characteristic mass spectral fragments and NMR data, and demonstrating the utility of ChatGPT\u20134o in forensic investigations.\n                  <\/jats:p>","DOI":"10.1111\/1556-4029.70223","type":"journal-article","created":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T11:10:31Z","timestamp":1763118631000},"page":"1040-1049","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>AI<\/scp>\n                    \u2010assisted identification of a novel vardenafil analog (\n                    <scp>KD<\/scp>\n                    \u2010027) adulterated in capsules"],"prefix":"10.1111","volume":"71","author":[{"given":"Yao\u2010Te","family":"Yen","sequence":"first","affiliation":[{"name":"Department of Forensic Science, Investigation Bureau, Ministry of Justice  New Taipei City Republic of China (Taiwan)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010Ti","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Forensic Science, Investigation Bureau, Ministry of Justice  New Taipei City Republic of China (Taiwan)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tzu\u2010Ching","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Forensic Science, Investigation Bureau, Ministry of Justice  New Taipei City Republic of China (Taiwan)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deng\u2010Ying","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Forensic Science, Investigation Bureau, Ministry of Justice  New Taipei City Republic of China (Taiwan)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen\u2010Hsiung","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Forensic Science, Investigation Bureau, Ministry of Justice  New Taipei City Republic of China (Taiwan)"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3928\/00989134\u201020070301\u201005"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsxm.2016.08.011"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/1735\u20101995.196618"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/13685530802273400"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.735708"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11030\u2010024\u201011016\u20102"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sxmr.2022.02.002"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.esxm.2021.100437"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40290\u2010023\u201000468\u2010w"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.22270\/ajprd.v9i4.1018"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.2147\/tcrm.s3336"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.5.4.923"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2012.02.014"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/20961790.2020.1829375"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm701400r"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/19440049.2013.766766"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2024.116563"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e15418"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e17253"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2019.121940"},{"key":"e_1_2_10_22_1","unstructured":"Taiwan Food and Drug Administration.Erectile dysfunction treatment compounds (analogues).2025[accessed 30 Oct 2025]. 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