{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T04:55:46Z","timestamp":1776056146529,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T00:00:00Z","timestamp":1763424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T00:00:00Z","timestamp":1763424000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Forensic Sciences"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Ecstasy<\/jats:italic>\n                    tablets are commonly associated with 3,4\u2010methylenedioxy\u2010methamphetamine (MDMA), but they often contain diverse psychoactive substances, including new psychoactive substances (NPS), which pose significant risks to users due to unknown composition and effects. This study analyzed 150\n                    <jats:italic>Ecstasy<\/jats:italic>\n                    tablets seized in Poland between 2020 and 2021, shaped as \u201cStormtrooper\u201d heads, to identify their chemical composition. Using gas chromatography\u2013mass spectrometry (GC\u2013MS) and ultra\u2010high\u2010performance liquid chromatography with photodiode array detection (UHPLC\u2010PDA), we detected MDMA, 3,4\u2010methylenedioxyamphetamine (MDA), and for the first time in Polish seizures, a novel phenylethylamine derivative\u20143,4\u2010methylenedioxy\u2010\n                    <jats:italic>N,N<\/jats:italic>\n                    \u2010dimethylamphetamine (MDDM). MDDM, a methyl analogue of MDMA and dimethyl analogue of MDA, has limited pharmacological data and reportedly mild psychoactive effects. Its presence is likely linked to impurities or by\u2010products formed during illicit MDMA synthesis. Quantitative analysis revealed that MDA occurred in the highest concentrations per tablet (26\u201374\u2009mg), followed by MDDM (11\u201328\u2009mg) and MDMA (3\u201311\u2009mg). Although MDDM alone is considered to have low potency, its co\u2010occurrence with other phenylethylamines may produce synergistic effects, potentially increasing toxicity. These findings shed light on synthetic routes in illicit MDMA production and highlight the unpredictable chemical composition of street drugs. The detection of multiple active substances\u2014even at low doses\u2014raises significant public health concerns, highlighting the necessity for continuous forensic monitoring and increased awareness of the dynamic and complex nature of synthetic drug markets.\n                  <\/jats:p>","DOI":"10.1111\/1556-4029.70226","type":"journal-article","created":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T04:21:33Z","timestamp":1763526093000},"page":"1058-1062","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["\u201cNew kid on the block\u201d\u2014\n                    <scp>MDDM<\/scp>\n                    as a new ingredient in\n                    <i>Ecstasy<\/i>\n                    tablets"],"prefix":"10.1111","volume":"71","author":[{"given":"Bogumi\u0142a","family":"Byrska","sequence":"first","affiliation":[{"name":"Institute of Forensic Research  Krakow Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karolina","family":"Masier","sequence":"additional","affiliation":[{"name":"Institute of Forensic Research  Krakow Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roman","family":"Stanaszek","sequence":"additional","affiliation":[{"name":"Institute of Forensic Research  Krakow Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0379\u20100738(98)00005\u2010x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11419\u2010024\u201000691\u20103"},{"key":"e_1_2_8_4_1","unstructured":"European Union Drugs Agency.European drug report 2025: Trends and developments. 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Available from:https:\/\/psychonautwiki.org\/wiki\/MDA. Accessed 7 Jul 2025."},{"key":"e_1_2_8_16_1","unstructured":"TripSit.MDA. TripSit's factsheets. Available from:https:\/\/tripsit.me\/factsheets. 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